Micelle-Enabled Suzuki-Miyaura Cross-Coupling of Heteroaryl Boronate Esters

被引：27

作者：

Guo, Pengfei ^{[1
]}

Zhang, Hao ^{[1
]}

Zhou, Jianguang ^{[1
]}

Gallou, Fabrice ^{[2
]}

Parmentier, Michael ^{[2
]}

Wang, Hui ^{[1
]}

机构：

[1] Suzhou Novartis Pharma Technol Co Ltd, Chem & Analyt Dev, Changshu 215537, Jiangsu, Peoples R China

[2] Novartis Pharma AG, Chem & Analyt Dev, CH-4056 Basel, Switzerland

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 14期

关键词：

ROOM-TEMPERATURE; ARYL; WATER; CATALYSIS; COPPER; GREEN; ACIDS;

D O I：

10.1021/acs.joc.8b00257

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a micellar protocol for Suzuki-Miyaura cross-coupling of heteroaryl boronic esters with aryl or heteroaryl halides. The micellar catalysis enables this coupling reaction to run under mild conditions, which avoids the decomposition of heteroaryl boronate esters and allows for high chemoselectivity for cross-coupling reaction with 6-chloropridine-2-boronic ester. The micellar protocol expands the scope of the cross-coupling reaction with challenging heteroaryl boronic esters and complements the existing cross-coupling methods for construction of heterobiaryl building blocks.

引用

页码：7523 / 7527

页数：5

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