Suzuki-Miyaura Cross-Coupling of Heteroaryl Halides and Arylboronic Acids in Continuous Flow

被引：77
|
作者：
Noel, Timothy [1 ]
Musacchio, Andrew J. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 19期
关键词：
CATALYST; MICROREACTOR; REACTORS;
D O I：
10.1021/ol202052q
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
General continuous-flow conditions for the Suzuki-Miyaura cross-coupling of heteroaryl halides and (hetero)arylboronic acids have been developed. A wide range of heterobiaryl products is obtained in excellent yields (20 examples) employing low catalyst loadings (0.05-1.5 mol % Pd).
引用
收藏
页码：5180 / 5183
页数：4
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