Total Synthesis of a Pyrrole Lactone Alkaloid, Longanlactone

被引：18

作者：

Reddy, Chada Raji ^{[1
]}

Reddy, Motatipally Damoder ^{[1
]}

Dilipkumar, Uredi ^{[1
]}

机构：

[1] CSIR Indian Inst Chem Technol, Div Nat Prod Chem, Hyderabad 500607, Andhra Pradesh, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 28期

关键词：

Total synthesis; Alkaloids; Nitrogen heterocycles; Lactones; Amino acids; NATURAL-PRODUCTS; QUARARIBEA METABOLITES; PROPARGYLATION; (-)-FUNEBRINE;

D O I：

10.1002/ejoc.201402563

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first asymmetric total synthesis of the natural pyrrole lactone longanlactone has been achieved. The key reactions, a Barbier propargylation and a Paal-Knorr pyrrole synthesis, have provided easy access to the target natural product from L-aspartic acid in six steps and 31% overall yield. The C-4 epimer of the natural product and propionyllonganlactone have also been prepared by this strategy.

引用

页码：6310 / 6313

页数：4

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