Practical asymmetric henry reaction catalyzed by a chiral Diamine-Cu(OAc)2 complex

被引：180

作者：

Arai, Takayoshi ^{[1
]}

Watanabe, Masahiko ^{[1
]}

Yanagisawa, Akira ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Sci, Dept Chem, Inage 2638522, Japan

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 18期

关键词：

D O I：

10.1021/ol7014362

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chiral diamine ligand 3 was designed and synthesized from (R,R)-1,2-diphenylethylenediamine, (S)-2,2'-dibromomethyl-1,1'-binaphthalene, and o-xylylene dibromide. The resulting 3-Cu(OAc)(2) complex was a highly efficient catalyst for the Henry reaction, giving the various nitroaldols with over 90% ee (up to > 99%). The reaction was performed in n-propyl alcohol at room temperature, and the Henry adducts were produced in high yield with excellent enantiomeric excess; these attributes are desirable in a catalyst for practical use.

引用

页码：3595 / 3597

页数：3

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