A new orally active antidiabetic vanadyl complex -: bis(α-furancarboxylato)oxovanadium(IV)

被引：46

作者：

Xie, MJ ^{[1
]}

Gao, LH

Ling, L

Liu, WP

Yan, SP

机构：

[1] Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China

[2] Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming 650031, Peoples R China

[3] Kunming Inst Precious Met, Kunming 650221, Peoples R China

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2005年 / 99卷 / 02期

基金：

中国国家自然科学基金;

关键词：

oxovanadium; alpha-furancarboxylic acid; insulinomimetic activity;

D O I：

10.1016/j.jinorgbio.2004.10.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bis(alpha-furanearboxylato)oxovanadium(IV) - a new orally active antidiabetic vanadyl complex has been synthesized, characterized, and tested for bioactivity as insulin-enhancing agents. The complex was administered intragastrically to both normal and STZ-diabetic rats for 4 weeks. The results show that the complex at a dose of 10.0 and 20.0 mg V kg(-1), could significantly lower the blood glucose level rats and ameliorated impaired glucose tolerance in STZ-diabetic, but not in normal rats. It was suggested that the complex exerted an antidiabetic effect in STZ-diabetic rats, which maybe was related to increasing the sensitivity to insulin. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：546 / 551

页数：6

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