A new orally active antidiabetic vanadyl complex -: bis(α-furancarboxylato)oxovanadium(IV)

被引：46
|
作者：
Xie, MJ [1 ]
Gao, LH
Ling, L
Liu, WP
Yan, SP
机构：
[1] Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
[2] Kunming Med Coll, Yunnan Pharmacol Labs Nat Prod, Kunming 650031, Peoples R China
[3] Kunming Inst Precious Met, Kunming 650221, Peoples R China
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2005年 / 99卷 / 02期
基金：
中国国家自然科学基金;
关键词：
oxovanadium; alpha-furancarboxylic acid; insulinomimetic activity;
D O I：
10.1016/j.jinorgbio.2004.10.033
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bis(alpha-furanearboxylato)oxovanadium(IV) - a new orally active antidiabetic vanadyl complex has been synthesized, characterized, and tested for bioactivity as insulin-enhancing agents. The complex was administered intragastrically to both normal and STZ-diabetic rats for 4 weeks. The results show that the complex at a dose of 10.0 and 20.0 mg V kg(-1), could significantly lower the blood glucose level rats and ameliorated impaired glucose tolerance in STZ-diabetic, but not in normal rats. It was suggested that the complex exerted an antidiabetic effect in STZ-diabetic rats, which maybe was related to increasing the sensitivity to insulin. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码：546 / 551
页数：6
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