Gukulenins A and B, Cytotoxic Tetraterpenoids from the Marine Sponge Phorbas gukulensis

被引：25
|
作者：
Park, Su Young [1 ]
Choi, Hyukjae [2 ]
Hwang, Hoosang [2 ]
Kang, Heonjoong [2 ]
Rho, Jung-Rae [1 ]
机构：
[1] Kunsan Natl Univ, Dept Oceanog, Jeonbuk 673701, South Korea
[2] Seoul Natl Univ, Ctr Marine Nat Prod & Drug Discovery, Sch Earth & Environm Sci, Seoul 151747, South Korea
来源：
JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 04期
关键词：
D O I：
10.1021/np900606h
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Gukulenins A (1) and B (2), both having an unprecedented skeleton with a bis-tropolone moiety, were isolated from the Korean marine sponge Phorbas gukulensis. They exhibited significant cytotoxicity against human pharynx, stomach, colon, and renal cancer cell lines in the range 0.05-0.80 mu M.
引用
收藏
页码：734 / 737
页数：4
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