Amyloid-β production in aged guinea pigs: atropine-induced enhancement is reversed by naloxone

被引：9
|
作者：
Ionov, Ilya D. [1 ]
Pushinskaya, Irina I. [2 ]
机构：
[1] Russian Acad Sci, Ctr Theoret Problems Phys & Chem Pharmacol, Moscow 117513, Russia
[2] Timpharm LTD, Moscow, Russia
来源：
NEUROSCIENCE LETTERS | 2010年 / 480卷 / 01期
关键词：
Alzheimer's disease; Aging; Cholinergic antagonist; Enkephalin; beta-Amyloid (1-40); beta-Amyloid (1-42); Guinea pigs; ACETYLCHOLINE-RELEASE; CEREBROSPINAL-FLUID; ALZHEIMERS-DISEASE; METHIONINE-ENKEPHALIN; FRONTAL-CORTEX; BRAIN; DEMENTIA; MODEL; RATS; HIPPOCAMPUS;
D O I：
10.1016/j.neulet.2010.06.010
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Advanced age, cholinergic deficit, and elevated brain levels of enkephalin are associated with sporadic Alzheimer's disease. The influence of these factors on production of amyloidogenic peptides (A beta) is uncertain. In the present experiments, the levels of 40/42 amino acid-residue A beta were measured in the brain cortex of guinea pigs aged 15-16 weeks (young) and 25-26 months (aged). As was found, injections of atropine (21 days, 5 mg/kg/day) increase A beta levels in aged but not young animals. This atropine-induced effect was antagonized by simultaneous injections of naloxone (3 mg/kg/day) whereas naloxone alone failed to affect A beta accumulation. These results are discussed in the light of a possible "acetylcholine - A beta" feedback loop and an influence of enkephalin on the loop function. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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页码：83 / 86
页数：4
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