Inhibitors of farnesyltransferase: 5-arylacryloylaminobenzophenones show antimalarial activity

被引：0
|
作者：
Wiesner, J [1 ]
Ortmann, R [1 ]
Mitsch, A [1 ]
Wissner, P [1 ]
Sattler, I [1 ]
Jomaa, H [1 ]
Schlitzer, M [1 ]
机构：
[1] Zentrum Pharmaforsch, Dept Pharm, D-81377 Munich, Germany
来源：
PHARMAZIE | 2003年 / 58卷 / 04期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：289 / 290
页数：2
相关论文
共 50 条
  • [41] FLAVIN ANALOGS WITH ANTIMALARIAL ACTIVITY AS GLUTATHIONE-REDUCTASE INHIBITORS
    BECKER, K
    CHRISTOPHERSON, RI
    COWDEN, WB
    HUNT, NH
    SCHIRMER, RH
    BIOCHEMICAL PHARMACOLOGY, 1990, 39 (01) : 59 - 65
  • [42] Exploring the Structure Activity Relationships of Imidazole Containing Tetrahydrobenzodiazepines as Farnesyltransferase Inhibitors: A QSAR Study
    Gaurav, Anand
    Gautam, Vertika
    Singh, Ranjit
    LETTERS IN DRUG DESIGN & DISCOVERY, 2011, 8 (06) : 506 - 515
  • [43] Exploring structure-activity relationships of tricyclic farnesyltransferase inhibitors using ECLiPS® libraries
    Rokosz, Laura L.
    Huang, Chia-Yu
    Reader, John C.
    Stauffer, Tara M.
    Southwick, Eileen C.
    Li, Ge
    Chelsky, Daniel
    Baldwin, John J.
    COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2006, 9 (07) : 545 - 558
  • [44] Structure-Guided Design of Cryptococcus neoformans Protein Farnesyltransferase Inhibitors with Antifungal Activity
    Wang, You
    Beese, Lorena
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2021, 77 : A103 - A103
  • [45] Understanding the antitumor activity of novel tricyclicpiperazinyl derivatives as farnesyltransferase inhibitors using CoMFA and CoMSIA
    Puntambekar, D. S.
    Giridhar, R.
    Yadav, M. R.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2006, 41 (11) : 1279 - 1292
  • [46] Quantitative structure activity relationship studies on a series of tetrahydroquinoline-based farnesyltransferase inhibitors
    Chaurasia, SH.
    Srivastava, A. K.
    Math, A.
    Srivastava, M. K.
    Pandey, A.
    OXIDATION COMMUNICATIONS, 2007, 30 (04): : 778 - 787
  • [47] Discovery and structure-activity relationships of imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase
    Ding, CZ
    Batorsky, R
    Bhide, R
    Chao, HGJ
    Cho, Y
    Chong, S
    Gullo-Brown, J
    Guo, P
    Kim, SH
    Lee, F
    Leftheris, K
    Miller, A
    Mitt, T
    Patel, M
    Penhallow, BA
    Ricca, C
    Rose, WC
    Schmidt, R
    Slusarchyk, WA
    Vite, G
    Yan, N
    Manne, V
    Hunt, JT
    JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (25) : 5241 - 5253
  • [48] Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors
    Lombardo, LJ
    Camuso, A
    Clark, J
    Fager, K
    Gullo-Brown, J
    Hunt, JT
    Inigo, I
    Kan, D
    Koplowitz, B
    Lee, F
    McGlinchey, K
    Qian, LG
    Ricca, C
    Rovnyak, G
    Traeger, S
    Tokarski, J
    Williams, DK
    Wu, LI
    Zhao, YF
    Manne, V
    Bhide, RS
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (07) : 1895 - 1899
  • [49] Lysosomal Activation by Farnesyltransferase Inhibitors Decreases Amyloid Pathology in 5XFAD Mice
    Cuddy, Leah
    Alia, O. Alia
    Salvo, Miranda
    Song, Peter
    Mazzulli, Joseph R.
    Vassar, Robert
    ANNALS OF NEUROLOGY, 2021, 90 : S75 - S76
  • [50] Non-thiol farnesyltransferase inhibitors: Structure-activity relationships of aralkylsubsituted benzophenones
    Mitsch, A
    Wissner, P
    Sattler, I
    Schlitzer, M
    ARCHIV DER PHARMAZIE, 2001, 334 (02) : 40 - 44
12345