Inhibitors of farnesyltransferase: 5-arylacryloylaminobenzophenones show antimalarial activity

被引:0
|
作者
Wiesner, J [1 ]
Ortmann, R [1 ]
Mitsch, A [1 ]
Wissner, P [1 ]
Sattler, I [1 ]
Jomaa, H [1 ]
Schlitzer, M [1 ]
机构
[1] Zentrum Pharmaforsch, Dept Pharm, D-81377 Munich, Germany
来源
PHARMAZIE | 2003年 / 58卷 / 04期
关键词
D O I
暂无
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:289 / 290
页数:2
相关论文
共 50 条
  • [1] Non-thiol farnesyltransferase inhibitors:: Utilization of an aryl binding site by 5-arylacryloylaminobenzophenones
    Mitsch, A
    Böhm, M
    Wissner, P
    Sattler, I
    Schlitzer, M
    BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (08) : 2657 - 2662
  • [2] Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity
    Ohkanda, J
    Lockman, JW
    Yokoyama, K
    Gelb, MH
    Croft, SL
    Kendrick, H
    Harrell, MI
    Feagin, JE
    Blaskovich, MA
    Sebti, SM
    Hamilton, AD
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (06) : 761 - 764
  • [3] Protein farnesyltransferase inhibitors exhibit potent antimalarial activity
    Nallan, L
    Bauer, KD
    Bendale, P
    Rivas, K
    Yokoyama, K
    Hornéy, CP
    Pendyala, PR
    Floyd, D
    Lombardo, LJ
    Williams, DK
    Hamilton, A
    Sebti, S
    Windsor, WT
    Weber, PC
    Buckner, FS
    Chakrabarti, D
    Gelb, MH
    Van Voorhis, WC
    JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (11) : 3704 - 3713
  • [4] Synthesis and antimalarial activity of novel peptidomimetic farnesyltransferase inhibitors
    Pusateri, EE
    Hamilton, AD
    Carrico, D
    Sebti, SM
    Gelb, MH
    Van Voorhis, WC
    Hucke, O
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U113 - U113
  • [5] Novel lead structures for antimalarial farnesyltransferase inhibitors
    Kettler, K
    Sakowski, J
    Wiesner, J
    Ortmann, R
    Jomaa, H
    Schlitzer, M
    PHARMAZIE, 2005, 60 (05): : 323 - 327
  • [6] Antimalarial activity of methylpiperazinyl-substituted benzophenone-based farnesyltransferase inhibitors
    Kettler, K
    Wiesner, J
    Ortmann, R
    Dahse, HM
    Jomaa, H
    Schlitzer, M
    PHARMAZIE, 2006, 61 (01): : 63 - 65
  • [7] The Recent Development of Farnesyltransferase Inhibitors as Anticancer and Antimalarial Agents
    Shen, Yan
    Qiang, Shengsheng
    Ma, Shutao
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2015, 15 (10) : 837 - 857
  • [8] In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability
    Carrico, D
    Ohkanda, J
    Kendrick, H
    Yokoyama, K
    Blaskovich, MA
    Bucher, CJ
    Buckner, FS
    Van Voorhis, WC
    Chakrabarti, D
    Croft, SL
    Gelb, MH
    Sebti, SM
    Hamilton, AD
    BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (24) : 6517 - 6526
  • [9] 2-(Aminoacylamino)benzophenones: farnesyltransferase inhibition and antimalarial activity
    Kettler, K
    Wiesner, J
    Fucik, K
    Sakowski, J
    Ortmann, R
    Dahse, HM
    Jomaa, H
    Schlitzer, M
    PHARMAZIE, 2005, 60 (09): : 677 - 682
  • [10] Structural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein Farnesyltransferase
    Hast, Michael A.
    Fletcher, Steven
    Cummings, Christopher G.
    Pusateri, Erin E.
    Blaskovich, Michelle A.
    Rivas, Kasey
    Gelb, Michael H.
    Van Voorhis, Wesley C.
    Sebti, Said M.
    Hamilton, Andrew D.
    Beese, Lorena S.
    CHEMISTRY & BIOLOGY, 2009, 16 (02): : 181 - 192