Controlling network ensembles

The field of optimal control typically requires the assumption of perfect knowledge of the system one desires to control, which is an unrealistic assumption for biological systems, or networks, typically affected by high levels of uncertainty. Here, we investigate the minimum energy control of network ensembles, which may take one of a number of possible realizations. We ensure the controller derived can perform the desired control with a tunable amount of accuracy and we study how the control energy and the overall control cost scale with the number of possible realizations. Our focus is in characterizing the solution of the optimal control problem in the limit in which the systems are drawn from a continuous distribution, and in particular, how to properly pose the weighting terms in the objective function. We verify the theory in three examples of interest: a unidirectional chain network with uncertain edge weights and self-loop weights, a network where each edge weight is drawn from a given distribution, and the Jacobian of the dynamics corresponding to the cell signaling network of autophagy in the presence of uncertain parameters. Application of the control usually requires complete knowledge of the system, which is rare for biological networks characterized by uncertainty. Klickstein et al. propose an optimal control for uncertain systems represented by network ensembles where only weight distributions for edges are known.