Long-chain non-coding RNA UCA1 inhibits renal tubular epithelial cell apoptosis by targeting microRNA-206 in diabetic nephropathy

被引：15
|
作者：
Yu, Rucui [1 ]
Zhang, Yan [2 ]
Lu, Zhihui [1 ]
Li, Jinhu [1 ]
Shi, Peng [3 ]
Li, Jianming [4 ]
机构：
[1] Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Tradit Chinese Med, Div Life Sci & Med, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China
[2] 105 Hosp Peoples Liberat Army, Anorectal Dept, Hefei, Anhui, Peoples R China
[3] Bengbu Med Coll, Dept Neurol, Affiliated Hosp 1, Bengbu, Peoples R China
[4] Beijing Hosp Chinese Tradit & Western Med, Dept Nephrol, 3 Yongding Rd,East St, Beijing 100039, Peoples R China
来源：
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2022年 / 128卷 / 01期
关键词：
Long-chain non-coding RNA UCA1; MiR-206; apoptosis; diabetic nephropathy; MESENCHYMAL TRANSITION; LUNG-CANCER; MIR-206; PROLIFERATION; PROGRESSION;
D O I：
10.1080/13813455.2019.1673431
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, the inhibitory effect of long-chain non-coding RNA urothelial carcinoma associated 1 (UCA1) on renal tubular epithelial cell apoptosis by targeting microRNA (miRNA)-206 in diabetic nephropathy (DN) was investigated through DN rat model. The results showed that UCA1 expression was significantly reduced in diabetic renal tubular epithelial tissues and HG-induced HK-2 cells. UCA1 significantly inhibited HG-induced apoptosis and inflammation of renal tubular epithelial cells in HK-2 cells. In addition, UCA1 can directly act as an anti-pro-cytokine by inhibiting the expression of miR-206, and finally inhibit the apoptosis and inflammation of renal tubular epithelial cells. We conclude that UCA1 inhibits renal tubular epithelial cell apoptosis by targeting miRNA-206 in DN and can be used as a potential therapeutic target for DN.
引用
收藏
页码：231 / 239
页数：9
相关论文
共 50 条
  • [31] Long non-coding RNA UCA1 promotes autophagy by targeting miR-96-5p in acute myeloid leukaemia
    Li, Jia Jia
    Chen, Xiao Feng
    Wang, Meng
    Zhang, Ping Ping
    Zhang, Feng
    Zhang, Jing Jing
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2020, 47 (05) : 877 - 885
  • [32] Long non-coding RNA UCA1 promotes breast cancer by upregulating PTP1B expression via inhibiting miR-206
    Li, Yi
    Zeng, Qingan
    Qiu, Jiliang
    Pang, Ting
    Xian, Jianzhong
    Zhang, Xuexia
    CANCER CELL INTERNATIONAL, 2019, 19 (01)
  • [33] Long non-coding RNA UCA1 promotes breast cancer by upregulating PTP1B expression via inhibiting miR-206
    Yi Li
    Qingan Zeng
    Jiliang Qiu
    Ting Pang
    Jianzhong Xian
    Xuexia Zhang
    Cancer Cell International, 19
  • [34] Long non-coding RNA UCA1 promotes cell progression by acting as a competing endogenous RNA of ATF2 in prostate cancer
    Zhang, Shilong
    Dong, Xinxin
    Ji, Tongyu
    Chen, Guoxiao
    Shan, Lei
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2017, 9 (02): : 366 - 375
  • [35] THE ROLE OF LONG-CHAIN NON-CODING RNA EGFR-AS1 IN THE DEVELOPMENT AND METASTASIS OF RENAL CARCINOMA
    Wang, Yang
    Li, Junhong
    Wang, Xilong
    Yu, Wandong
    Wang, Yangyun
    Zhang, Jun
    Shi, Guowei
    ACTA MEDICA MEDITERRANEA, 2020, 36 (01): : 565 - 569
  • [36] Diagnostic value and cognitive regulatory roles of long non-coding RNA UCA1 in Alzheimer's disease
    Zhang, Yongjin
    Wu, Fangping
    NEUROSCIENCE LETTERS, 2024, 829
  • [37] Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling
    Fan, Yu
    Shen, Bing
    Tan, Mingyue
    Mu, Xinyu
    Qin, Yan
    Zhang, Fang
    Liu, Yong
    FEBS JOURNAL, 2014, 281 (07) : 1750 - 1758
  • [38] Long non-coding RNA urothelial carcinoma associated 1 ( UCA1) mediates radiation response in prostate cancer
    Ghiam, Alireza Fotouhi
    Taeb, Samira
    Huang, Xiaoyong
    Huang, Vincent
    Ray, Jessica
    Scarcello, Seville
    Hoey, Christianne
    Jahangiri, Sahar
    Fokas, Emmanouil
    Loblaw, Andrew
    Bristow, Robert G.
    Vesprini, Danny
    Boutros, Paul
    Liu, Stanley K.
    ONCOTARGET, 2017, 8 (03) : 4668 - 4689
  • [39] Long Non-Coding RNA Urothelial Carcinoma Associated 1 (UCA1): Insight into Its Role in Human Diseases
    Li, Feng
    Hu, Chang-Ping
    CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2015, 25 (03): : 191 - 197
  • [40] HUMAN LONG NON-CODING RNA (LNCRNA) CCAT1 AND UCA1 REGULATE PROINFLAMMATORY RESPONSE AND CELL MIGRATION IN HUMAN AND MOUSE INTESTINAL EPITHELIAL CELLS
    Law, Ivy Ka Man
    Padua, David M.
    Iliopoulos, Dimitrios
    Pothoulakis, Charalabos
    GASTROENTEROLOGY, 2018, 154 (06) : S183 - S184
12345