Long-chain non-coding RNA UCA1 inhibits renal tubular epithelial cell apoptosis by targeting microRNA-206 in diabetic nephropathy

被引：15
|
作者：
Yu, Rucui [1 ]
Zhang, Yan [2 ]
Lu, Zhihui [1 ]
Li, Jinhu [1 ]
Shi, Peng [3 ]
Li, Jianming [4 ]
机构：
[1] Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Tradit Chinese Med, Div Life Sci & Med, 17 Lujiang Rd, Hefei 230001, Anhui, Peoples R China
[2] 105 Hosp Peoples Liberat Army, Anorectal Dept, Hefei, Anhui, Peoples R China
[3] Bengbu Med Coll, Dept Neurol, Affiliated Hosp 1, Bengbu, Peoples R China
[4] Beijing Hosp Chinese Tradit & Western Med, Dept Nephrol, 3 Yongding Rd,East St, Beijing 100039, Peoples R China
来源：
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2022年 / 128卷 / 01期
关键词：
Long-chain non-coding RNA UCA1; MiR-206; apoptosis; diabetic nephropathy; MESENCHYMAL TRANSITION; LUNG-CANCER; MIR-206; PROLIFERATION; PROGRESSION;
D O I：
10.1080/13813455.2019.1673431
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, the inhibitory effect of long-chain non-coding RNA urothelial carcinoma associated 1 (UCA1) on renal tubular epithelial cell apoptosis by targeting microRNA (miRNA)-206 in diabetic nephropathy (DN) was investigated through DN rat model. The results showed that UCA1 expression was significantly reduced in diabetic renal tubular epithelial tissues and HG-induced HK-2 cells. UCA1 significantly inhibited HG-induced apoptosis and inflammation of renal tubular epithelial cells in HK-2 cells. In addition, UCA1 can directly act as an anti-pro-cytokine by inhibiting the expression of miR-206, and finally inhibit the apoptosis and inflammation of renal tubular epithelial cells. We conclude that UCA1 inhibits renal tubular epithelial cell apoptosis by targeting miRNA-206 in DN and can be used as a potential therapeutic target for DN.
引用
收藏
页码：231 / 239
页数：9
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