Metallothionein in snail Cd and Cu metabolism

被引：206
|
作者：
Dallinger, R [1 ]
Berger, B [1 ]
Hunziker, P [1 ]
Kagi, JHR [1 ]
机构：
[1] UNIV ZURICH, INST BIOCHEM, CH-8057 ZURICH, SWITZERLAND
来源：
NATURE | 1997年 / 388卷 / 6639期
关键词：
D O I：
10.1038/40785
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Terrestrial snails tolerate elevated concentrations of cadmium and copper, accumulating both metals in their soft tissues1. The snails are able to inactivate the toxic cadmium while meeting their metabolic requirement for copper. Here we report evidence for the metabolic discrimination between the two metals based on the existence of distinct metallothionein isoforms, one dedicated to cadmium detoxification and another to copper regulation.
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页码：237 / 238
页数：2
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