APOE ε4 genotype is associated with an earlier onset of chronic temporal lobe epilepsy

被引：77

作者：

Briellmann, RS

Torn-Broers, Y

Busuttil, BE

Major, BJ

Kalnins, RM

Olsen, M

Jackson, GD

Frauman, AG

Berkovic, SF

机构：

[1] Univ Melbourne, Epilepsy Res Inst, Melbourne, Vic 3081, Australia

[2] Univ Melbourne, Brain Imaging Res Inst, Melbourne, Vic 3081, Australia

[3] Univ Melbourne, Dept Clin Pharmacol & Therapeut, Melbourne, Vic 3081, Australia

[4] Univ Melbourne, Dept Pathol, Melbourne, Vic 3081, Australia

[5] Austin & Repatriat Med Ctr, Melbourne, Vic, Australia

[6] Royal Childrens Hosp, Murdoch Inst, Victorian Clin Genet Serv, Melbourne, Vic, Australia

来源：

NEUROLOGY | 2000年 / 55卷 / 03期

关键词：

D O I：

10.1212/WNL.55.3.435

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors analyzed the association betwen APOE epsilon 4 genotype and clinical and MRI findings in 43 refractory temporal lobe epilepsy patients. The distribution of the alleles were normal. Ten patients (23%) had an APOE epsilon 4 allele and had an earlier onset of habitual seizures (with epsilon 4 5 +/- 5 years; without epsilon 4 15 +/- 10 years). Quantitative MRI findings were not influenced by the APOE epsilon 4 genotype. APOE epsilon 4 may shorten the latency between an initial injury and seizure onset.

引用

页码：435 / 437

页数：3

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