ApoE ε4 is not associated with posictal confusion in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

被引：4

作者：

Andres Kauffman, Marcelo ^{[1
,2
]}

Pereira-de-Silva, Nahuel ^{[1
]}

Consalvo, Damian ^{[1
]}

Kochen, Silvia ^{[1
]}

机构：

[1] Hosp Ramos Mejia, Div Neurol, Ctr Epilepsia, CEFYBO,CONICET, RA-1221 Buenos Aires, DF, Argentina

[2] Sanatorio Franchin, Serv Neurol, Neurogenet Lab, Buenos Aires, DF, Argentina

来源：

EPILEPSY RESEARCH | 2009年 / 85卷 / 2-3期

关键词：

ApoE; Temporal lobe epilepsy; Gene; Polymorphism; GENETIC ASSOCIATION; THERAPEUTIC TARGET; DISEASE; SUSCEPTIBILITY; METAANALYSIS;

D O I：

10.1016/j.eplepsyres.2009.03.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A previous report found an association between ApoE isoforms and postictal confusion in medically intractable temporal lobe epilepsy (TLE). We performed a molecular epidemiology study in an independent sample of 77 TLE patients. We failed to replicate the original allelic association between ApoE epsilon 4 allele and postictal confusion in our population (chi(2) = 1.67; d.f. = 1; p=0.2). Thus, the association between ApoE epsilon 4 allele and postictal confusion still needs to be fully investigated in different and independent populations. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：311 / 313

页数：3

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