(E)-3-(4-Chlorophenyl)-1-(2-fluoro-4-methoxyphenyl)-2-propen-1-one

被引：3
|
作者：
Bailey, Nicholas [1 ]
Atanes, Alaina [1 ]
Ashburn, Bradley O. [1 ]
机构：
[1] Univ Hawaii West Oahu, Ashburn Grp, Math Nat & Hlth Sci Div, 91-1001 Farrington Hwy, Kapolei, HI 96707 USA
来源：
MOLBANK | 2021年 / 2021卷 / 01期
基金：
美国国家卫生研究院;
关键词：
chalcone; synthesis; aldol; leishmaniasis; neglected tropical disease; CHALCONES;
D O I：
10.3390/M1184
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Natural products known as chalcones show promise as chemotherapeutic agents for the neglected tropical disease known as leishmaniasis. Our objective is to synthesize new targets of opportunity that may lead to better treatments of this debilitating disease. Claisen-Schmidt condensation of 4-chlorobenzaldehyde with 2'-fluoro-4'-methoxyacetophenone using aqueous sodium hydroxide in ethanol yielded the novel compound (E)-3-(4-chlorophenyl)-1-(2-fluoro-4-methoxyphenyl)-2-propen-1-one. The product was obtained in good yield and purity after recrystallization from ethyl acetate/hexane. With the known antiparasitic properties of halogenated chalcones, this novel compound is suitable for antileishmanial activity study.
引用
收藏
页码：1 / 4
页数：4
相关论文
共 50 条
  • [21] 3-(4-Bromophenyl)-1-(3-thienyl)-2-propen-1-one (BTC)
    1600, Munksgaard Int Publ. Ltd., Copenhagen K, Denmark (51):
  • [22] 3-(4-BROMOPHENYL)-1-(3-THIENYL)-2-PROPEN-1-ONE (BTC)
    HE, YP
    WU, QG
    SU, GB
    ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 1995, 51 : 1167 - 1168
  • [23] 1-[4-(4-BROMOBENZYLIDENEAMINO)PHENYL]-3-(4-BROMOPHENYL)-2-PROPEN-1-ONE
    LI, ZD
    SU, GB
    HUANG, XY
    ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 1994, 50 : 1788 - 1790
  • [24] 1-(4-chlorophenyl)-3-[3-(4-chlorophenyl)-pyrazol-1-yl]-propan-1-one
    Sankaranarayanan, Jagadis
    Mandel, Sarah M.
    Krause, Jeanette A.
    Gudmundsdottir, Anna D.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2007, 63 : O721 - O723
  • [25] (E)-1-(2-Aminophenyl)-3-(4-chlorophenyl)prop-2-en-1-one
    Abonia, Rodrigo
    Cabrera, Lorena
    Quiroga, Jairo
    Insuasty, Braulio
    Moreno-Fuquen, Rodolfo
    Kennedy, Alan R.
    MOLBANK, 2016, (04)
  • [26] (E)-3-(4-chlorophenyl)-1-(2-furyl)prop-2-en-1-one
    Fun, Hoong-Kun
    Patil, P. S.
    Jebas, Samuel Robinson
    Dharmaprakash, S. M.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O1530 - U2636
  • [27] SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF 1-[1-(NAPHTHALENYL)]-3-(4-NITROPHENYL)-2-PROPEN-1-ONE
    ESWARAMOORTHY, S
    PONNUSWAMY, MN
    RAJU, KS
    NANJUNDAN, S
    KRISHNASAMY, V
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE, 1994, 209 (08): : 669 - 672
  • [28] (E)-3-(4-chlorophenyl)-1-(2-thienyl)prop-2-en-1-one
    Fun, Hoong-Kun
    Jebas, Samuel Robinson
    Patil, P. S.
    Dharmaprakash, S. M.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O1592 - U3172
  • [29] (2E)-3-(4-Butoxyphenyl)-1-(4-chlorophenyl)prop-2-en-1-one
    Yathirajan, H. S.
    Sreevidya, T. V.
    Narayana, B.
    Sarojini, B. K.
    Bolte, Michael
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2006, 62 : O5923 - O5924
  • [30] (2E)-1-(4-Chlorophenyl)-3-(4-nitrophenyl) prop-2-en-1-one
    Yamuna, T. S.
    Yathirajan, H. S.
    Jasinski, Jerry P.
    Keeley, Amanda C.
    Narayana, B.
    Sarojini, B. K.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2013, 69 : O790 - +
12345