The ever-expanding role of HIF in tumour and stromal biology

被引：337
|
作者：
LaGory, Edward L. [1 ]
Giaccia, Amato J. [1 ]
机构：
[1] Stanford Univ, Dept Radiat Oncol, Div Radiat & Canc Biol, Stanford, CA 94305 USA
来源：
NATURE CELL BIOLOGY | 2016年 / 18卷 / 04期
关键词：
HYPOXIA-INDUCIBLE FACTOR; CANCER-ASSOCIATED FIBROBLASTS; ENDOTHELIAL GROWTH-FACTOR; FATTY-ACID OXIDATION; PYRUVATE-KINASE M2; T-REG CELLS; FACTOR; 1-ALPHA; FACTOR-I; SUPPRESSOR-CELLS; BREAST-CANCER;
D O I：
10.1038/ncb3330
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Low oxygen tension (hypoxia) is a hallmark of cancer that influences cancer cell function, but is also an important component of the tumour microenvironment as it alters the extracellular matrix, modulates the tumour immune response and increases angiogenesis. Here we discuss the regulation and role of hypoxia and its key transcriptional mediators, the hypoxia-inducible factor (HIF) family of transcription factors, in the tumour microenvironment and stromal compartments.
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页码：356 / 365
页数：10
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