Phytochemical analysis and anti-inflammatory evaluation of compounds from an aqueous extract of Croton cajucara Benth.

被引：28
|
作者：
Nascimento, Adamara M. [1 ,2 ]
Maria-Ferreira, Daniele [1 ,3 ]
Dal Lin, Fernando T. [3 ]
Kimura, Alexandre [1 ]
de Santana-Filho, Arquimedes P. [1 ]
Werner, Maria Fernanda de P.
Iacomini, Marcell [1 ]
Sassaki, Guilherme L. [1 ]
Cipriani, Thales R. [1 ]
de Souza, Lauro M. [4 ]
机构：
[1] Univ Fed Parana, Dept Bioquim & Biol Mol, CP 19046, BR-81531980 Curitiba, Parana, Brazil
[2] Univ Fed Acre, Ctr Multidisciplinar, Campus Floresta, BR-69980000 Cruzeiro Do Sul, AC, Brazil
[3] Univ Fed Parana, Dept Farmacol, BR-81531980 Curitiba, Parana, Brazil
[4] Fac Pequeno Principe, Inst Pesquisa Pele Pequeno Principe, BR-80250060 Curitiba, Parana, Brazil
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2017年 / 145卷
关键词：
Croton cajucara; Flavonoids; Anti-inflammatory activity; LC MS; MASS-SPECTROMETRY; FLAVONOID GLYCOSIDES; PHENOLIC-COMPOUNDS; ACID-DERIVATIVES; ESSENTIAL OIL; C-GLYCOSIDES; IDENTIFICATION; EUPHORBIACEAE; LEAVES; MS;
D O I：
10.1016/j.jpba.2017.07.032
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Croton cajucara Benth. is a medicinal plant popularly used in the Brazilian Amazonia, where it is known as sacaca, being consumed as tea, decoction or infusion of the leaves and stem bark. From a decoction of the leaves, a comprehensive phytochemical analysis was developed by liquid chromatography-mass spectrometry. Many compounds were identified for the first time in C. cajucara, such as O-glycosides of kaempferol and quercetin, flavonoid-C-glycosides, tannins and cinnamic acid derivatives. These compounds were fractionated by polarity and assayed for their anti-inflammatory activity, using a model of mice edema, induced by an intraplantar injection of carrageenan. All fractions exhibited anti-inflammatory properties. (C) 2017 Published by Elsevier B.V.
引用
收藏
页码：821 / 830
页数：10
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