Highly chemoselective and enantioselective recognition of serine by a fluorescent probe

被引：5

作者：

Wang, Yalin ^{[1
]}

Tian, Jun ^{[1
]}

Zhao, Feng ^{[1
,2
]}

Chen, Yu ^{[1
]}

Huo, Bingyi ^{[1
]}

Yu, Shanshan ^{[1
]}

Yu, Xiaoqi ^{[1
]}

Pu, Lin ^{[2
]}

机构：

[1] Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Peoples R China

[2] Univ Virginia, Dept Chem, McCormick Rd, Charlottesville, VA 22904 USA

来源：

TETRAHEDRON LETTERS | 2021年 / 66卷

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

Fluorescent sensor; Amino acids; Serine; Chemoselective; Enantioselective;

D O I：

10.1016/j.tetlet.2020.152803

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A diarylacetylene-containing 1,1'-bi-2-naphthol derivative (R)-2 was designed and synthesized. This compound in combination with Zn2+ represents the first chemoselective as well as enantioselective fluorescent probe for the biologically important amino acid serine. It was found that L-serine can greatly enhance the fluorescence of the probe at lambda = 471 nm but o-serine and 17 other common amino acids cannot. An enantioselective fluorescence enhancement ratio [ef = (I-L - I-0)/(I-D - I-0) = Delta I-L/Delta I-D] of 15 was observed for the response of (R)-2 + Zn2+ toward serine. (C) 2021 Elsevier Ltd. All rights reserved.

引用

页数：5

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