Structure-activity relationships (SAR) of triazine derivatives: Promising antimicrobial agents

被引：88
|
作者：
Liu, Hao [1 ]
Long, Sihui [1 ]
Rakesh, K. P. [1 ]
Zha, Gao-Feng [1 ,2 ]
机构：
[1] Wuhan Inst Technol, Hubei Key Lab Novel Reactor & Green Chem Technol, Hubei Engn Res Ctr Adv Fine Chem, Key Lab Green Chem Proc,Minist Educ,Sch Chem Engn, Wuhan 430205, Hubei, Peoples R China
[2] Karolinska Inst, Ming Wai Lau Ctr Reparat Med, Hong Kong, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2020年 / 185卷
基金：
中国国家自然科学基金;
关键词：
Triazines; Antibacterial; Antifungal; Minimum inhibitory concentration; SAR; ANTIBACTERIAL ACTIVITY; STAPHYLOCOCCUS-AUREUS; BIOLOGICAL EVALUATION; ANTITUMOR-ACTIVITY; MOLECULAR DOCKING; DESIGN; POTENT; INHIBITORS; DISCOVERY; ANALOGS;
D O I：
10.1016/j.ejmech.2019.111804
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The emergence of drug resistance has created unmet medical need for the development of new classes of antibiotics. Innovation of new antibacterial agents with new mode of action remains a high priority universally. Triazines are six-membered, nitrogen-containing heterocyclic scaffold with a wide range of pharmaceutical properties such as antibacterial, antifungal, anticancer, antioxidants, antitubercular, antimalarial, anti-HIV, anticonvulsant, anti-inflammatory, antiulcer, and analgesic activities. The present review focuses on the recent developments in the area of medicinal chemistry to discover various chemical structures as potential antimicrobial agents and their structure-activity relationships (SAR) studies are also discussed for further rational design of this kind of derivatives. (C) 2019 Elsevier Masson SAS. All rights reserved.
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页数：15
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