Thiazole - A promising scaffold for antituberculosis agents and structure-activity relationships studies

被引：0

作者：

Zhao, Xuanming ^{[1
]}

Di, Jing ^{[2
]}

Luo, Dingjie ^{[3
]}

Verma, Rameshwari ^{[4
]}

Verma, Santosh Kumar ^{[4
]}

Verma, Shekhar ^{[5
]}

Ravindar, Lekkala ^{[6
]}

Koshle, Anubhuti ^{[7
]}

Dewangan, Hitesh Kumar ^{[7
]}

Gupta, Raksha ^{[7
]}

Chandra, Sunita ^{[7
]}

Deshpande, Samta ^{[8
]}

Kamal ^{[9
]}

Vaishnav, Yogesh ^{[5
]}

Rakesh, Kadalipura P. ^{[10
]}

机构：

[1] Yulin Univ, Energy Engn Coll, Yulin 71900, Peoples R China

[2] Yulin Univ, Phys Educ Coll, Yulin 71900, Peoples R China

[3] Xian Traff Engn Inst, Sch Humanities & Management, Xian 710000, Peoples R China

[4] Yulin Univ, Sch Chem & Chem Engn, Yulin 719000, Shaanxi, Peoples R China

[5] Guru Ghasidas Vishwavidyalaya, Dept Pharm, Bilaspur 495009, Chhattisgarh, India

[6] Univ Kebangsaan Malaysia, Fac Sci & Technol, Dept Chem Sci, Bangi 43600, Selangor, Malaysia

[7] Shri Rawatpura Sarkar Univ, Dept Chem, Raipur 492015, Chhattisgarh, India

[8] Shri Shankaracharya Tech Campus, Dept Appl Phys, Bhilai Durg 490020, Chhattisgarh, India

[9] Indian Inst Technol Jammu, Dept Chem, Jammu 181221, India

[10] Univ North Carolina Chapel Hill, Biomed Res Imaging Ctr, Dept Radiol, Chapel Hill, NC 27599 USA

来源：

BIOORGANIC CHEMISTRY | 2025年 / 154卷

关键词：

Thiazole; Heterocyclic; In vitro; In vivo; Antituberculosis; SAR; Drugs; IN-SILICO; ANTIMICROBIAL ACTIVITY; DRUG DISCOVERY; DERIVATIVES; DESIGN; TUBERCULOSIS; INHIBITORS; ANTIBACTERIAL; TOXICITY; SULFONYL;

D O I：

10.1016/j.bioorg.2024.108035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Research on thiazole derivatives has been a popular topic in medicine and one of the most active fields in heterocyclic chemistry. Pharmacological and industrial researchers have been studying thiazole-containing derivatives in great detail because they have a lot of biological uses. These compounds are one of the best examples of a five-membered heterocyclic compound that has a lot of potential and has had a lot of success in recent decades. Investigating viable hybrid designs utilizing thiazole is critical for the development of new antituberculosis medications. This article offers a thorough overview of the latest advancements in thiazolecontaining hybrids, offering potential therapeutic applications as anti-TB drugs. We also discussed the structure-activity correlations (SAR) of the powerful thiazole moiety and its several functional groups, along with a few potential molecular targets.

引用

页数：15

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