A circadian-rhythmic transcription factor DBP upregulates expression of CCR5, a major co-receptor for HIV-1

被引：0
|
作者：
Moriuchi, M [1 ]
Moriuchi, H [1 ]
机构：
[1] Nagasaki Univ, Grad Sch Biomed Sci, Div Med Virol, Dept Mol Microbiol & Immunol, Nagasaki, Japan
来源：
XV INTERNATIONAL AIDS CONFERENCE: BASIC SCIENCE | 2004年
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D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Expression of CCR5, a major coreceptor for HIV-1 is regulated by a number of transcription factors. Here we report that DBP transcription factor binds to and transactivates CCR5 promoter and that overexpression of DBP enhances cell surface CCR5 expression. DBP activity is under circadian rhythm and appears to mediate circadian expression of CCR5. Circadian expression of CCR5 by DBP may play an important role in the pathogenesis of HIV-1 disease and influence efficacy of HIV-1 entry inhibitors targeting CCR5.
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页码：5 / 8
页数：4
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