Switching the regioselectivity in the copper-catalyzed synthesis of iodoimidazo[1,2-a]pyridines

被引：43
|
作者：
Samanta, Sadhanendu [1 ]
Jana, Sourav [1 ]
Mondal, Susmita [1 ]
Monir, Kamarul [1 ]
Chandra, Swapan K. [1 ]
Hajra, Alakananda [1 ]
机构：
[1] Visva Bharati, Dept Chem, Santini Ketan 731235, W Bengal, India
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 22期
关键词：
ONE-POT SYNTHESIS; OXIDATIVE CYCLIZATION; COUPLING REACTION; IMIDAZOHETEROCYCLES; TRIFLUOROMETHYLATION; 2-AMINOPYRIDINE; NITROOLEFINS; CONSTRUCTION; DIAMINATION; ANNULATION;
D O I：
10.1039/c6ob00656f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A unique copper-catalyzed binucleophilic switching of 2-aminopyridine has been developed for the regioselective synthesis of 2- and 3-iodoimidazo[1,2-a]pyridines using alkenes/alkynes as coupling partners in the presence of molecular iodine under aerobic reaction conditions. This method was also applied to the synthesis of 2-iodo-3-phenylbenzo[d]imidazo[2,1-b]thiazoles. This protocol offers an easy route towards the synthesis of 2,3-diarylimidazo[1,2-a]pyridines.
引用
收藏
页码：5073 / 5078
页数：6
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