Copper-catalyzed C-N bond formation with imidazo[1,2-a]pyridines

被引：28

作者：

Sun, Kai ^{[1
]}

Mu, Shiqiang ^{[1
]}

Liu, Zhenhua ^{[2
]}

Feng, Ranran ^{[1
]}

Li, Yali ^{[1
]}

Pang, Kui ^{[1
]}

Zhang, Bing ^{[3
]}

机构：

[1] Anyang Normal Univ, Coll Chem & Chem Engn, Anyang 455000, Peoples R China

[2] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes, Jinan, Shandong, Peoples R China

[3] Zhengzhou Univ, Coll Chem & Energy, Zhengzhou 450001, Henan, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 36期

基金：

中国国家自然科学基金;

关键词：

DEHYDROGENATIVE COUPLING REACTION; METAL-FREE CONDITIONS; H AMINATION; REGIOSELECTIVE SULFENYLATION; C-SP3-H BONDS; AMINO KETONES; IMIDAZOHETEROCYCLES; IMIDAZOPYRIDINES; IMIDATION; STRATEGY;

D O I：

10.1039/c8ob01853g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient Cu-catalyzed method for direct C-N bond formation on the C-3 position of imidazo[1,2-a]pyridines is reported. The robust copper catalyst tolerated a wide range of functional groups and set the stage for the synthesis of diversely decorated imidazo[1,2-a]pyridines. Preliminary experimental results show that the reaction mechanism is consistent with C-3 radical functionalization.

引用

页码：6655 / 6658

页数：4

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