An efficient synthesis of 3,4-dihydropyran-2-one derivatives by Lewis base-catalyzed tandem Michael addition and lactonization

被引：19

作者：

Tozawa, T

Fujisawa, H

Mukaiyama, T

机构：

[1] Kitasato Inst, TCI, Ctr Basic Res, Kita Ku, Tokyo 114003, Japan

[2] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

来源：

CHEMISTRY LETTERS | 2004年 / 33卷 / 11期

关键词：

D O I：

10.1246/cl.2004.1454

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convenient one-pot preparation of 3,4-dihydropyran-2-one derivatives by Michael addition of silyl enolate derived from phenyl ester with alpha,beta-unsaturated ketones in the presence of a Lewis base catalyst such as tetrabutylammonium phenoxide was developed. In this catalytic cycle, 3,4-dihydropyran-2-ones were produced in good to excellent yields via intramolecular cyclization of in situ formed Michael-adducts.

引用

页码：1454 / 1455

页数：2

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