Synthesis of 2-amino-5-(1-methyl-5-nitro-[4-3H]-2-imidazolyl)-1,3,4-thiadiazole

被引：0
|
作者：
Chauviere, G
Rousseau, B
Pillon, F
Perie, J
机构：
[1] Univ Toulouse 3, Grp Chim Organ Biol, UMR 5623, F-31062 Toulouse, France
[2] CEA Saclay, Serv Mol Marquees, Dept Biol Cellulaire & Mol, F-91191 Gif Sur Yvette, France
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1998年 / 41卷 / 01期
关键词：
Megazol; CL; 64855; 5-nitro imidazoles; reductive desiodination; tritiated water;
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
2-Amino-5-(1-methyl-5-nitro-4-iodo-2-imidazoyl)-1,3,4-thiadiazole (5) was prepared from imidazole via a 4-steps sequence. Reductive desiodination of 5 using a tetrahydrofuran solution of NaBH4 in the presence of tritiated water provided the title compound (specific radioactivity 12.6 Ci/mmol) in one step.
引用
收藏
页码：47 / 51
页数：5
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