Single-cell analysis of self-antigen-specific CD4 T cells reveals the B helper signature and the peripheral reservoir of autoreactive T cells in autoimmune hepatitis

被引:0
|
作者
Renand, Amedee [1 ]
Inaki, Cervera-Marzal [2 ]
Laurine, Gil [2 ]
Chuang, Dong [2 ]
Erwan, Kervagoret [1 ]
Auble, Helene [3 ]
Habes, Sarah [4 ]
Anais, Cardon [1 ]
Judor, Jean-Paul [1 ]
Mosnier, Jean-Francois [5 ]
Brouard, Sophie [1 ]
Gournay, Jerome [4 ]
Milpied, Pierre [2 ]
Conchon, Sophie [1 ]
机构
[1] Nantes Univ, Ctr Rech Transplantat & Immunol, INSERM, UMR 1064, Nantes, France
[2] Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France
[3] CHU Nantes, Ctr Invest Clin Gastronutr, Nantes, France
[4] CHU Nantes, Serv Hepatogastroenterol & Assistance Nutr, Nantes, France
[5] CHU Nantes, Serv Anat & Cytol Pathol, Nantes, France
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
THU110
引用
收藏
页码:S194 / S194
页数:1
相关论文
共 50 条
  • [21] Antigen Presenting B Cells Facilitate CD4 T Cell Cooperation Resulting in Enhanced Generation of Effector and Memory CD4 T Cells
    Kroeger, David R.
    Rudulier, Christopher D.
    Bretscher, Peter A.
    PLOS ONE, 2013, 8 (10):
  • [22] Single-cell transcriptomic and T cell antigen receptor analysis of human cytomegalovirus (hCMV)-specific memory T cells reveals effectors and pre-effectors of CD8+- and CD4+-cytotoxic T cells
    Kar, Raunak
    Chattopadhyay, Somdeb
    Sharma, Anjali
    Sharma, Kirti
    Sinha, Shreya
    Arimbasseri, Gopalakrishnan Aneeshkumar
    Patil, Veena S.
    IMMUNOLOGY, 2024, 172 (03) : 420 - 439
  • [23] Self-Tolerance Checkpoints in CD4 T Cells Specific for a Peptide Derived from the B Cell Antigen Receptor
    Detanico, Thiago
    Heiser, Ryan A.
    Aviszus, Katja
    Bonorino, Cristina
    Wysocki, Lawrence J.
    JOURNAL OF IMMUNOLOGY, 2011, 187 (01): : 82 - 91
  • [24] Langerhans cells activate naive self-antigen-specific CD8 T cells in the steady state
    Mayerova, D
    Parke, EA
    Bursch, LS
    Odumade, OA
    Hogquist, KA
    IMMUNITY, 2004, 21 (03) : 391 - 400
  • [25] Autoimmune hepatitis in mice is driven by activation of autoreactive CD4 T cells in the liver and formation of ectopic lymphoid tissue
    Preti, M.
    Schlott, L.
    Luebbering, D.
    Krzikalla, D.
    Mueller, A-L
    Schwinge, D.
    Weidemann, S.
    Lohse, A. W.
    Weiler-Normann, C.
    Schramm, C.
    Carambia, A.
    Herkel, J.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 762 - 763
  • [26] Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4(+) T cells analyzed at the single-cell level
    Sornasse, T
    Larenas, PV
    Davis, KA
    deVries, JE
    Yssel, H
    JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02): : 473 - 483
  • [27] Single-cell transcriptomics of human gut T cells identifies cytotoxic CD4+CD8A+ T cells related to mouse CD4 cytotoxic T cells
    Tanemoto, Shun
    Sujino, Tomohisa
    Miyamoto, Kentaro
    Moody, Jonathan
    Yoshimatsu, Yusuke
    Ando, Yoshinari
    Koya, Ikuko
    Harada, Yosuke
    Tojo, Anna Okuzawa
    Ono, Keiko
    Hayashi, Yukie
    Takabayashi, Kaoru
    Okabayashi, Koji
    Teratani, Toshiaki
    Mikami, Yohei
    Nakamoto, Nobuhiro
    Hosoe, Naoki
    Ogata, Haruhiko
    Hon, Chung-Chau
    Shin, Jay W.
    Kanai, Takanori
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [28] Langerhans cells apoptosis mediated by CD4 T cells requires antigen specific cell contact
    Warren, DT
    Dandridge, L
    Genebriera, J
    Pradhan, S
    Timares, L
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 122 (03) : A131 - A131
  • [29] In vivo activation of antigen-specific CD4 T cells
    Jenkins, MK
    Khoruts, A
    Ingulli, E
    Mueller, DL
    McSorley, SJ
    Reinhardt, RL
    Itano, A
    Pape, KA
    ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 : 23 - 45
  • [30] Role of endogenous CD4 T cells in the potential development of autoreactive B cell repertoire.
    Choudhury, A
    Chen, FQ
    Maldonado, MA
    Eisenberg, RA
    ARTHRITIS AND RHEUMATISM, 2002, 46 (09): : S455 - S455