Effects of anti-IL-5 monoclonal antibody on the murine model of nasal allergy

被引：19
|
作者：
Asakura, K [1 ]
Saito, H [1 ]
Watanabe, M [1 ]
Ogasawara, H [1 ]
Matsui, T [1 ]
Kataura, A [1 ]
机构：
[1] Sapporo Med Univ, Dept Otolaryngol, Chuo Ku, Sapporo, Hokkaido 060, Japan
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1998年 / 116卷 / 01期
关键词：
nasal allergy; anti-IL-5 monoclonal antibody; murine model;
D O I：
10.1159/000023924
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
IL-5 is known to be closely related to the infiltration, activation and proliferation of eosinophils. In this study, we evaluated the in vivo effects of anti-IL-5 monoclonal antibody (mAb) in the murine model of nasal allergy. The mAb treatment inhibited the antigen-induced late phase eosinophilia, but had no effects on the number of basophilic cells. It also inhibited early phase nasal symptoms, and tended to inhibit histamine hypersensitivity. These findings suggest that IL-5 plays an important role in the pathogenesis of allergic nasal disorders.
引用
收藏
页码：49 / 52
页数：4
相关论文
共 50 条
  • [21] German Asthma Net: Characterisation of responders to anti-IL-5 and anti-IL-5(R) therapy
    Bal, Christina
    Stoshikj, Slagjana
    Renner, Andreas
    Milger, Katrin
    Skowasch, Dirk
    Schulz, Christian
    Jandl, Margret
    Schmidt, Olaf
    Ehmann, Rainer
    Zehetmayer, Sonja
    Taube, Christian
    Hamelmann, Eckard
    Buhl, Roland
    Korn, Stephanie
    Idzko, Marco
    PULMONOLOGY, 2025, 31 (01):
  • [22] INHIBITORY EFFECT OF THE TRFK-5 ANTI-IL-5 ANTIBODY IN A GUINEA-PIG MODEL OF ASTHMA
    MAUSER, PJ
    PITMAN, A
    WITT, A
    FERNANDEZ, X
    ZURCHER, J
    KUNG, T
    JONES, H
    WATNICK, AS
    EGAN, RW
    KREUTNER, W
    ADAMS, GK
    AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 148 (06): : 1623 - 1627
  • [23] Successful treatment of eosinophilic otitis media associated with severe bronchial asthma with an anti-IL-5 monoclonal antibody, mepolizumab
    Suzaki, Isao
    Kimura, Yurika
    Tanaka, Akihiko
    Hirano, Kojiro
    Ishibashi, Atsushi
    Mizuyoshi, Tomomi
    Ando, Izumi
    Kitajima, Tatsuya
    Watanabe, So
    Hinohira, Yasuyuki
    Kobayashi, Hitome
    AURIS NASUS LARYNX, 2019, 46 (01) : 141 - 146
  • [24] Anti-IL-5 therapy and DRESS
    Khan, Sujoy
    CANADIAN MEDICAL ASSOCIATION JOURNAL, 2010, 182 (09) : 941 - 941
  • [25] Anti-IL-5 therapies for asthma
    Farne, Hugo A.
    Wilson, Amanda
    Milan, Stephen J.
    Banchoff, Emma
    Yang, Freda
    Powell, Colin V. E.
    COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2022, (07):
  • [26] The demise of Anti-IL-5 for asthma, or not
    O'Byrne, Paul M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2007, 176 (11) : 1059 - 1060
  • [27] Effects of chronic anti-interleukin-5 monoclonal antibody treatment in a murine model of pulmonary inflammation
    Garlisi, CG
    Kung, TT
    Wang, P
    Minnicozzi, M
    Umland, SP
    Chapman, RW
    Stelts, D
    Crawley, Y
    Falcone, A
    Myers, JG
    Jones, H
    Billah, MM
    Kreutner, W
    Egan, RW
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1999, 20 (02) : 248 - 255
  • [28] Anti-IL-5 and hypereosinophilic syndromes
    Sutton, SA
    Assa'ad, AH
    Rothenberg, ME
    CLINICAL IMMUNOLOGY, 2005, 115 (01) : 51 - 60
  • [29] The trials and tribulations of anti-IL-5 ...
    Hansel, TT
    Sterk, PJ
    Holgate, ST
    Barnes, PJ
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 109 (03) : 575 - 575
  • [30] Targeting the IL-5 pathway in eosinophilic asthma: A comparison of anti-IL-5 versus anti-IL-5 receptor agents
    Jackson, David J.
    Wechsler, Michael E.
    Brusselle, Guy
    Buhl, Roland
    ALLERGY, 2024, 79 (11) : 2943 - 2952
12345