Allergic bronchopulmonary aspergillosis in a patient with ankylosing spondylitis treated with adalimumab

被引:0
|
作者
Suzuki, Yudai [1 ]
Takasaka, Naoki [1 ]
Matsubayashi, Sachi [1 ]
Kojima, Ayako [1 ]
Shinfuku, Kyota [1 ]
Hasegawa, Tsukasa [1 ]
Yamada, Masami [1 ]
Fujisaki, Ikumi [1 ]
Seki, Aya [1 ]
Seki, Yoshitaka [1 ]
Ishikawa, Takeo [1 ]
Kuwano, Kazuyoshi [2 ]
机构
[1] Jikei Univ, Div Resp Dis, Dept Internal Med, Daisan Hosp, 4-11-1 Izumihoncho Komae, Tokyo 2018601, Japan
[2] Jikei Univ Hosp, Div Resp Dis, Dept Internal Med, Tokyo, Japan
来源
RESPIROLOGY CASE REPORTS | 2021年 / 9卷 / 08期
关键词
Adalimumab; allergic bronchopulmonary aspergillosis; ankylosing spondylitis; anti-tumour necrosis factor-alpha antibody;
D O I
10.1002/rcr2.805
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
We herein report a case of allergic bronchopulmonary aspergillosis (ABPA) that occurred in a man treated with adalimumab for ankylosing spondylitis (AS). A 69-year-old man with a history of ankylosing spondylitis treated by adalimumab, an anti-tumour necrosis factor-alpha (TNF-alpha) antibody, developed cough and wheezing. Chest computed tomography showed obstruction of dilated left upper lobe bronchus by high attenuation mucus as well as central bronchiectasis. Both Aspergillus-specific immunoglobulin E (IgE) and Aspergillus precipitating antibody were positive and Aspergillus fumigatus was detected in a sputum culture. According to the new diagnostic criteria, the patient was diagnosed with ABPA. His condition rapidly improved after the withdrawal of adalimumab and initiation of prednisolone and itraconazole. Anti-TNF-alpha antibody might cause ABPA through both aggravation of the host's T-helper 2 immunological response and anti-fungal response.
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页数:4
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