Current approaches for the treatment of male infertility with stem cell therapy

被引:17
|
作者
Pourmoghadam, Zahra [1 ,2 ,3 ,4 ]
Aghebati-Maleki, Leili [2 ,5 ]
Motalebnezhad, Morteza [1 ]
Yousefi, Bahman [3 ]
Yousefi, Mehdi [3 ,5 ]
机构
[1] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran
[3] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran
[4] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran
[5] Tabriz Univ Med Sci, Dept Immunol, Tabriz, Iran
关键词
fertility; male infertility; spermatogenesis; stem cells; transplantation; MALE GERM-CELLS; IN-VITRO; RETROGRADE EJACULATION; KLINEFELTERS-SYNDROME; RESTORES FERTILITY; SELF-RENEWAL; SPERM; SPERMATOGENESIS; MEN; DIFFERENTIATION;
D O I
10.1002/jcp.26577
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Infertility is the inability to conceive after having regular unprotected sexual intercourse for more than 12 months and it can be caused by reproductive problems of men, women, or both, but sometimes the cause of infertility is unknown. At least 30 million men around the world suffer from infertility, most of whom are in Africa and Eastern Europe. Since infertility problems can have devastating emotional effects on couples as well as negative effects on the society, treatment of infertility is very important, as a result of which many studies have been carried out in this field and many treatments have been proposed. Recently, due to several advances in infertility treatments, more than 80% of infertile couples now have children. Among these treatments, stem cells as undifferentiated cells and because of their self-renewing and high differentiating potential have been considered by researchers. This review explained different types of male infertility and various therapies, with emphasis on stem cells therapy.
引用
收藏
页码:6455 / 6469
页数:15
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