How to develop ACC1 inhibitors targeting lipid metabolism and oncogenic signaling pathways effectively and safely

被引：0
|
作者：
Liu, Ningshu [1 ]
Bone, Wilhelm [1 ]
Velan, Sendhil S. [2 ]
Doddapuneni, Krishnarao [2 ]
Yaligar, Jadegoud [2 ]
Thede, Kai Thede [1 ]
Moenning, Ursula [1 ]
Shi, Xiaohe [2 ]
Tian, Xianfeng [2 ]
Petrova, Elissaveta [1 ]
von Nussbaum, Franz [1 ]
Mumberg, Dominik [1 ]
Brands, Michael [1 ]
Ziegelbauer, Karl [1 ]
机构：
[1] Bayer Pharma AG, Berlin, Germany
[2] SBIC, Singapore, Singapore
来源：
CANCER RESEARCH | 2015年 / 75卷
关键词：
D O I：
10.1158/1538-7445.AM2015-1129
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1129
引用
收藏
页数：1
相关论文
共 38 条
  • [31] Wheat Germ Peptide Ameliorates Hyperglycemia and Hyperlipidemia in Diabetic Rats Through Modulation of Suppressor of Cytokine Signaling-3/Insulin Receptor Substrate-1/Protein Kinase B and Lipid Metabolism Pathways
    Song, Haizhao
    Lu, Jing
    Zhang, Yu
    Shen, Xinchun
    CHEMISTRY & BIODIVERSITY, 2025,
  • [32] Elevated expression of ISY1, APOA-1, SYNE1, MTG1, and MMP10 at HCC initiation: HCC specific protein network involving interactions of key regulators of lipid metabolism, EGFR signaling, MAPK, and splicing pathways
    Shaglouf, Laila H. Faraj
    Ranjpour, Maryam
    Wajid, Saima
    Tandon, Rakesh
    Vasudevan, Karisangal Ramaswamy
    Jain, Swatantra Kumar
    PROTOPLASMA, 2023, 260 (02) : 651 - 662
  • [33] Elevated expression of ISY1, APOA-1, SYNE1, MTG1, and MMP10 at HCC initiation: HCC specific protein network involving interactions of key regulators of lipid metabolism, EGFR signaling, MAPK, and splicing pathways
    Laila H. Faraj Shaglouf
    Maryam Ranjpour
    Saima Wajid
    Rakesh Tandon
    Karisangal Ramaswamy Vasudevan
    Swatantra Kumar Jain
    Protoplasma, 2023, 260 : 651 - 662
  • [34] Ilex paraguariensis A.St.-Hil. improves lipid metabolism in high-fat diet-fed obese rats and suppresses intracellular lipid accumulation in 3T3-L1 adipocytes via the AMPK-dependent and insulin signaling pathways
    Kudo, Maya
    Gao, Ming
    Hayashi, Misa
    Kobayashi, Yukiko
    Yang, Jinwei
    Liu, Tonghua
    FOOD & NUTRITION RESEARCH, 2024, 68
  • [35] Ameliorative Effects of Malonyl Ginsenoside from Panax ginseng on Glucose-Lipid Metabolism and Insulin Resistance via IRS1/PI3K/Akt and AMPK Signaling Pathways in Type 2 Diabetic Mice
    Wang, Dong-Sheng
    Wang, Jia-Mei
    Zhang, Fu-Rui
    Lei, Feng-Jie
    Wen, Xin
    Song, Jia
    Sun, Guang-Zhi
    Liu, Zhi
    AMERICAN JOURNAL OF CHINESE MEDICINE, 2022, 50 (03): : 863 - 882
  • [36] Serine Threonine-Protein Kinase-Derived IW13 Improves Lipid Metabolism via C/EBP-α/SREBP1/FAS Signaling Pathways in HFD-Induced Zebrafish In Vivo Larval Model
    Guru, Ajay
    Sudhakaran, Gokul
    Namasivayam, S. Karthick Raja
    Seenivasan, Boopathi
    Pasupulieti, Mukesh
    Arockiaraj, Jesu
    Moovendhan, Meivelu
    APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2023, 195 (08) : 4851 - 4863
  • [37] Serine Threonine-Protein Kinase-Derived IW13 Improves Lipid Metabolism via C/EBP-α/SREBP1/FAS Signaling Pathways in HFD-Induced Zebrafish In Vivo Larval Model
    Applied Biochemistry and Biotechnology, 2023, 195 : 4851 - 4863
  • [38] Platinum complexes inhibit HER-2 enriched and triple-negative breast cancer cells metabolism to suppress growth, stemness and migration by targeting PKM/LDHA and CCND1/BCL2/ATG3 signaling pathways
    Bai, Xue
    Ali, Amjad
    Lv, Zhimin
    Wang, Na
    Zhao, Xing
    Hao, Huifang
    Zhang, Yongmin
    Rahman, Faiz-Ur
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 224
1234