Screening breast cancer patients for Norwegian ATM mutations

被引：9
|
作者：
Laake, K
Vu, P
Andersen, TI
Erikstein, B
Kåresen, R
Lonning, PE
Skovlund, E
Borresen-Dale, AL [1 ]
机构：
[1] Norwegian Radium Hosp, Dept Genet, N-0310 Oslo, Norway
[2] Univ Oslo, Ulleval Hosp, Dept Oncol, N-0407 Oslo, Norway
[3] Univ Oslo, Ulleval Hosp, Dept Surg, N-0407 Oslo, Norway
[4] Norwegian Radium Hosp, Dept Oncol, N-0310 Oslo, Norway
[5] Norwegian Radium Hosp, Clin Res Off, N-0310 Oslo, Norway
[6] Haukeland Hosp, Dept Oncol, N-5021 Bergen, Norway
来源：
BRITISH JOURNAL OF CANCER | 2000年 / 83卷 / 12期
关键词：
ataxia telangiectasia; breast neoplasms; heterozygote detection; polymerase chain reaction; breast cancer risk; Norwegian founder mutation;
D O I：
10.1054/bjoc.2000.1519
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
483 Norwegian breast cancer patients were screened for six different ataxia telangiectasia mutated (ATM) mutations previously found to account for 83% of the disease alleles in Norwegian ataxia telangiectasia (AT) patients. Only one carrier was found. These results provide no evidence in favour of an excess risk of breast cancer associated with heterozygosity for classical AT mutations, but remain consistent with a maximum 2.4-fold increased risk. (C) 2000 Cancer Research Campaign.
引用
收藏
页码：1650 / 1653
页数：4
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