Effect of Glyprolines on Homeostasis of Gastric Mucosa in Rats with Stress Ulcers

被引：6

作者：

Falalyeyeva, T. M. ^{[2
]}

Samonina, G. E. ^{[1
]}

Beregovaya, T. V. ^{[2
]}

Andreeva, L. A. ^{[3
]}

Dvorshchenko, E. V. ^{[2
]}

机构：

[1] Moscow MV Lomonosov State Univ, Fac Biol, Dept Human & Anim Physiol, Moscow, Russia

[2] TG Shevchenko Kiev Natl Univ, Fac Biol, Dept Pharmaceut Physiol, Kiev, Ukraine

[3] Russian Acad Sci, Inst Mol Genet, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2010年 / 149卷 / 01期

关键词：

glyprolines; stress; gastric mucosa; lipid peroxidation; antioxidant defense enzymes;

D O I：

10.1007/s10517-010-0866-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Pro-Gly-Pro and its metabolite Gly-Pro effectively prevented the development of erosive and ulcerative lesions of the gastric mucosa in rats under conditions of water-immersion restraint stress by restoring the oxidatant-antioxidant balance in the total fraction of gastric mucosa cells. Pro-Gly was least effective in this respect. We conclude that glyprolines hold much promise as pharmaceutical products, which can be used in gastroenterological practice for the prevention and therapy of ulcer disease of the stomach and duodenum.

引用

页码：26 / 28

页数：3

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