Comparison of colorectal cancer outcomes in young adults and octogenarians

被引：12

作者：

Prabhakaran, Swetha ^{[1
]}

Kong, Joseph Cherng ^{[1
,3
,4
,5
]}

Williams, Evan ^{[1
]}

Bell, Stephen ^{[1
,2
]}

Warrier, Satish ^{[1
,3
]}

Simpson, Paul ^{[1
,2
]}

Chin, Martin ^{[1
,2
]}

Skinner, Stewart ^{[1
,2
]}

Carne, Peter ^{[1
,2
]}

机构：

[1] Alfred Hosp, Dept Colorectal Surg, 55 Commercial Rd, Melbourne, Vic 3004, Australia

[2] Monash Univ, Alfred Hosp, 55 Commercial Rd, Melbourne, Vic 3004, Australia

[3] Peter MacCallum Canc Ctr, Div Canc Res, Melbourne, Vic, Australia

[4] Univ Melbourne, Peter MacCallum Canc Ctr, Melbourne, Vic, Australia

[5] Monash Univ, Cent Clin Sch, Melbourne, Vic, Australia

来源：

AMERICAN JOURNAL OF SURGERY | 2022年 / 223卷 / 05期

关键词：

Colorectal cancer; Young adults; Octogenarians; EARLY-ONSET; CHEMOTHERAPY; SURVIVAL; AGE;

D O I：

10.1016/j.amjsurg.2021.08.013

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: This study aimed to characterise the outcomes associated with colorectal cancer (CRC), comparing young adults (<50 years), patients of screening age (50-79 years), and octogenarians (>80 years). Methods: All consecutive CRC resections with curative intent were recruited into this study from a prospectively maintained CRC database at a tertiary academic centre. Results: A total of 745 eligible cases were identified. Five-year survival in young adults was poorer than that of patients of screening age. Young adults had the highest incidence of rectal cancer resections, and presented with the most advanced tumour stages. Independent associations for poorer survival in young adults were increased nodal stage, the presence of distal metastases, and loss of MLH1/PMS2 staining on immunohistochemistry. Young adults had similar survival to octogenarians, when comparing patients treated with curative intent, regardless of oncological treatment. (c) 2021 Elsevier Inc. All rights reserved.

引用

页码：951 / 956

页数：6

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