Microbial genome dynamics in CNS pathogenesis

被引:9
|
作者
Davidsen, T.
Koomey, M.
Tonjum, T.
机构
[1] Natl Hosp Norway, Radiumhosp Med Ctr, Inst Microbiol, Ctr Mol Biol & Neurosci, NO-0027 Oslo, Norway
[2] Univ Oslo, Inst Microbiol, NO-0027 Oslo, Norway
[3] Univ Oslo, Inst Mol Life Sci, NO-0316 Oslo, Norway
关键词
CNS infections; meningitis; phase variation; recombination; transformation; mutator activity;
D O I
10.1016/j.neuroscience.2007.01.059
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The balancing act between microbes and their host in commensal and disease states needs to be deciphered in order to fully treat and combat infectious diseases. The elucidation of microbial genome dynamics in each instance is therefore required. In this context, the major bacterial meningitis pathogens are Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae. In prokaryotic CNS pathogenesis both the intact organism as well as its released components can elicit disease, often resulting in neurological sequelae, neurodegeneration or fatal outcome. The study of microbial virulence in CNS disease is expected to generate findings that yield new information on the general mechanisms of brain edema and excitatory neuronal disturbances due to meningitis, with significant potential for discoveries that can directly influence and inspire new strategies for prevention and treatment of this serious disease. (C) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:1375 / 1387
页数:13
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