RETRACTED: MiR-93 blocks cell cycle progression and promotes apoptosis in uterine leiomyoma cells by targeting CCND1 (Retracted Article)

被引：8

作者：

Zhang, Donghong ^{[1
]}

Liu, Enling ^{[1
]}

Tian, Wei ^{[2
]}

Zhang, Zhiyong ^{[2
]}

Wang, Liqun ^{[1
]}

Li, Jun ^{[1
]}

机构：

[1] Tangshan Gongren Hosp, Obstet & Gynecol, Tangshan, Peoples R China

[2] Tangshan Gongren Hosp, Expt Diagnost, Tangshan, Peoples R China

来源：

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2020年 / 303卷 / 09期

关键词：

CCND1; miR-93; uterine leiomyoma; G870A POLYMORPHISM; CANCER; GENE; ASSOCIATION; GROWTH;

D O I：

10.1002/ar.24308

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Uterine leiomyoma (UL) is the most common type of benign tumor in the women's reproductive system. A number of genes has been found to play an important role in the initiation and progression of UL, including miRNAs. In this study, our results exhibited that miR-93, a member of mir-106b-25 cluster, significantly reduced the cell viability, promoted cell cycle arrest, caused apoptosis, and inhibited migration in UL cells (p < .01). Moreover, our results have provided experimental evidence that miR-93 regulated the biological functions of UL cells by targeting CCND1.

引用

页码：2372 / 2381

页数：10

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