Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025

被引：34
|
作者：
Xu, Xinya [1 ]
Zhang, Xiaoyong [1 ]
Nong, Xuhua [1 ]
Wang, Jie [1 ]
Qi, Shuhua [1 ]
机构：
[1] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
来源：
MARINE DRUGS | 2017年 / 15卷 / 02期
关键词：
Penicillium brevicompactum; Brevianamide; Mycochromenic acid derivative; cytotoxicity; antifouling; NATURAL-PRODUCTS; IMMUNOSUPPRESSANT; APPROXIMATION; BIOSYNTHESIS; EXCHANGE;
D O I：
10.3390/md15020043
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new compounds (1-4), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungus Penicillium brevicompactum DFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configurations of 1 and 2 were determined by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compound 9 showed moderate cytotoxicity against human colon cancer HCT116 cell line with IC50 value of 15.6 mu M. In addition, 3 and 5 had significant antifouling activity against Bugula neritina larval settlement with EC50 values of 13.7 and 22.6 mu M, respectively. The NMR data of 6, 8, and 9 were assigned for the first time.
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页数：10
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