Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025

被引：34
|
作者：
Xu, Xinya [1 ]
Zhang, Xiaoyong [1 ]
Nong, Xuhua [1 ]
Wang, Jie [1 ]
Qi, Shuhua [1 ]
机构：
[1] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China
来源：
MARINE DRUGS | 2017年 / 15卷 / 02期
关键词：
Penicillium brevicompactum; Brevianamide; Mycochromenic acid derivative; cytotoxicity; antifouling; NATURAL-PRODUCTS; IMMUNOSUPPRESSANT; APPROXIMATION; BIOSYNTHESIS; EXCHANGE;
D O I：
10.3390/md15020043
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new compounds (1-4), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungus Penicillium brevicompactum DFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configurations of 1 and 2 were determined by quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compound 9 showed moderate cytotoxicity against human colon cancer HCT116 cell line with IC50 value of 15.6 mu M. In addition, 3 and 5 had significant antifouling activity against Bugula neritina larval settlement with EC50 values of 13.7 and 22.6 mu M, respectively. The NMR data of 6, 8, and 9 were assigned for the first time.
引用
收藏
页数：10
相关论文
共 50 条
  • [1] Cytotoxic and antiviral tetramic acid derivatives from the deep-sea-derived fungus Trichobotrys effuse DFFSCS021
    Sun, Yu-Lin
    Wang, Jie
    Wang, Yi-Fei
    Zhang, Xiao-Yong
    Nong, Xu-Hua
    Chen, Mao-Yun
    Xu, Xin-Ya
    Qi, Shu-Hua
    TETRAHEDRON, 2015, 71 (49) : 9328 - 9332
  • [2] Oxindole alkaloids from the fungus Penicillium commune DFFSCS026 isolated from deep-sea-derived sediments
    Xu, Xinya
    Zhang, Xiaoyong
    Nong, Xuhua
    Wei, Xiaoyi
    Qi, Shuhua
    TETRAHEDRON, 2015, 71 (04) : 610 - 615
  • [3] Alkaloids from the Deep-Sea-Derived Fungus Aspergillus westerdijkiae DFFSCS013
    Peng, Jiang
    Zhang, Xiao-Yong
    Tu, Zheng-Chao
    Xu, Xin-Ya
    Qi, Shu-Hua
    JOURNAL OF NATURAL PRODUCTS, 2013, 76 (05): : 983 - 987
  • [4] Three New Chromone Derivatives from the Deep-Sea-Derived Fungus Penicillium thomii
    Yang, Fan
    Liu, Yu
    Zhang, Xiaoqian
    Liu, Wan
    Qiao, Ying
    Xu, Wei
    Li, Qin
    Cheng, Zhongbin
    RECORDS OF NATURAL PRODUCTS, 2022, : 174 - 178
  • [5] Three new terpenoid derivatives from the deep-sea-derived fungus Aspergillus sydowii DFFSCS007
    Ren, Xu-Meng
    Wu, Ke-Yue
    Qi, Shu-Hua
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2024,
  • [6] Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021
    Yao, Qifeng
    Wang, Jie
    Zhang, Xiaoyong
    Nong, Xuhua
    Xu, Xinya
    Qi, Shuhua
    MARINE DRUGS, 2014, 12 (12): : 5902 - 5915
  • [7] New Phthalides and Isochromanone Derivatives from the Deep-Sea-Derived Fungus Penicillium bialowiezense A3
    Lv, Yinghui
    Gong, Linfeng
    Zhang, Gaiyun
    Wu, Jingna
    Hong, Bihong
    Niu, Siwen
    CHEMISTRY & BIODIVERSITY, 2025, 22 (01)
  • [8] New antifouling macrodiolides from the deep-sea-derived fungus Trichobotrys effuse DFFSCS021
    Sun, Yu-Lin
    Zhang, Xiao-Yong
    Nong, Xu-Hua
    Xu, Xin-Ya
    Qi, Shu-Hua
    TETRAHEDRON LETTERS, 2016, 57 (03) : 366 - 370
  • [9] Statins Diversity Revealed by the Deep-Sea-Derived Fungus Penicillium viridicatum
    Zhang, Meng
    Chao, Rong
    Wang, Jia-Jian
    Xu, Zi-Han
    Zhang, Ji-Hong
    Meng, Da-Li
    Wu, Tai-Zong
    Yang, Xian-Wen
    MARINE DRUGS, 2025, 23 (02)
  • [10] Unstable Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Cladosporium sphaerospermum EIODSF 008
    Liang, Xiao
    Huang, Zhong-Hui
    Ma, Xuan
    Qi, Shu-Hua
    MARINE DRUGS, 2018, 16 (11):
12345