We improve upon indirect diagonalization arguments for lower bounds on explicit problems within the polynomial hierarchy. Our contributions are summarized as follows. 1. We present a technique that uniformly improves upon most known nonlinear time lower bounds for nondeterminism and alternating computation, on both subpolynomial (n(o(1))) space RAMs and sequential one-tape machines with random access to the input. We obtain improved lower bounds for Boolean satisfiability (SAT), as well as all NP-complete problems that have efficient reductions from SAT, and Sigma(k)-SAT, for constant k >= 2. For example, SAT cannot be solved by random access machines using n(root 3) time and subpolynomial space. 2. We show how indirect diagonalization leads to time-space lower bounds for computation with bounded nondeterminism. For both the random access and multitape Turing machine models, we prove that for all k >= 1, there is a constant c(k) > 1 such that linear time with n(1/k) nondeterministic bits is not contained in deterministic n(ck) time with subpolynomial space. This is used to prove that satisfiability of Boolean circuits with n inputs and n(k) size cannot be solved by deterministic multitape Turing machines running in n(k.ck) time and subpolynomial space.