Taurine Promotes the Cartilaginous Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Vitro

被引：5
|
作者：
Yao, Xiuhua [1 ]
Huang, Huiling [1 ]
Li, Zhou [2 ]
Liu, Xiaohua [3 ]
Fan, Weijia [1 ]
Wang, Xinping [4 ]
Sun, Xuelian [3 ]
Zhu, Jianmin [3 ]
Zhou, Hongrui [2 ]
Wei, Huaying [3 ]
机构：
[1] Tianjin Huanhu Hosp, Tianjin Neurosurg Inst, Tianjin Key Lab Cerebral Vasc & Neurodegenerat Di, 6 JiZhao Rd, Tianjin 300350, Peoples R China
[2] NewScen Coast Biopharmaceut Co Ltd, TEDA, 65 Sixth Ave, Tianjin 300457, Peoples R China
[3] Arthro Anda Tianjin Biol Technol Co Ltd, 2F Bldg 2,Tian Bao Ind Pk,Xi Qi Rd, Tianjin 300308, Peoples R China
[4] Tianjin Huanhu Hosp, Dept Neurol, 6 JiZhao Rd, Tianjin 300350, Peoples R China
来源：
NEUROCHEMICAL RESEARCH | 2017年 / 42卷 / 08期
基金：
国家高技术研究发展计划(863计划);
关键词：
Human mesenchymal stem cells; Umbilical cord; Taurine; Chondrogenesis; HUMAN ARTICULAR CHONDROCYTES; TISSUE GROWTH-FACTOR; PROGENITOR CELLS; BONE-MARROW; CHONDROGENIC DIFFERENTIATION; STIMULATES PROLIFERATION; PRIMARY CULTURES; EXPRESSION; OSTEOBLAST; PATHWAY;
D O I：
10.1007/s11064-017-2252-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Taurine has been reported to influence osteogenic differentiation, but the role of taurine on cartilaginous differentiation using human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) remains unclear. In this study, we investigated the effect of taurine (0, 1, 5 and 10 mM) on the proliferation and chondrogenesis of hUC-MSCs by analyzing cell proliferation, accumulation of glycosaminoglycans and expression of cartilage specific mRNA. The results show though taurine did not affected the proliferation of hUC-MSCs, 5 mM of taurine is sufficient to enhanced the accumulation of glycosaminoglycans and up-regulate cartilage specific mRNA expression, namely collagen type II, aggrecan and SOX9. Taurine also inhibits chondrocyte dedifferentiation by reducing expression of collagen type I mRNA. Taken together, our study reveals that taurine promotes and maintains the chondrogenesis of hUC-MSCs.
引用
收藏
页码：2344 / 2353
页数：10
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