Taurine Promotes the Cartilaginous Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Vitro

被引：5
|
作者：
Yao, Xiuhua [1 ]
Huang, Huiling [1 ]
Li, Zhou [2 ]
Liu, Xiaohua [3 ]
Fan, Weijia [1 ]
Wang, Xinping [4 ]
Sun, Xuelian [3 ]
Zhu, Jianmin [3 ]
Zhou, Hongrui [2 ]
Wei, Huaying [3 ]
机构：
[1] Tianjin Huanhu Hosp, Tianjin Neurosurg Inst, Tianjin Key Lab Cerebral Vasc & Neurodegenerat Di, 6 JiZhao Rd, Tianjin 300350, Peoples R China
[2] NewScen Coast Biopharmaceut Co Ltd, TEDA, 65 Sixth Ave, Tianjin 300457, Peoples R China
[3] Arthro Anda Tianjin Biol Technol Co Ltd, 2F Bldg 2,Tian Bao Ind Pk,Xi Qi Rd, Tianjin 300308, Peoples R China
[4] Tianjin Huanhu Hosp, Dept Neurol, 6 JiZhao Rd, Tianjin 300350, Peoples R China
来源：
NEUROCHEMICAL RESEARCH | 2017年 / 42卷 / 08期
基金：
国家高技术研究发展计划(863计划);
关键词：
Human mesenchymal stem cells; Umbilical cord; Taurine; Chondrogenesis; HUMAN ARTICULAR CHONDROCYTES; TISSUE GROWTH-FACTOR; PROGENITOR CELLS; BONE-MARROW; CHONDROGENIC DIFFERENTIATION; STIMULATES PROLIFERATION; PRIMARY CULTURES; EXPRESSION; OSTEOBLAST; PATHWAY;
D O I：
10.1007/s11064-017-2252-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Taurine has been reported to influence osteogenic differentiation, but the role of taurine on cartilaginous differentiation using human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) remains unclear. In this study, we investigated the effect of taurine (0, 1, 5 and 10 mM) on the proliferation and chondrogenesis of hUC-MSCs by analyzing cell proliferation, accumulation of glycosaminoglycans and expression of cartilage specific mRNA. The results show though taurine did not affected the proliferation of hUC-MSCs, 5 mM of taurine is sufficient to enhanced the accumulation of glycosaminoglycans and up-regulate cartilage specific mRNA expression, namely collagen type II, aggrecan and SOX9. Taurine also inhibits chondrocyte dedifferentiation by reducing expression of collagen type I mRNA. Taken together, our study reveals that taurine promotes and maintains the chondrogenesis of hUC-MSCs.
引用
收藏
页码：2344 / 2353
页数：10
相关论文
共 50 条
  • [1] Taurine Promotes the Cartilaginous Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Vitro
    Xiuhua Yao
    Huiling Huang
    Zhou Li
    Xiaohua Liu
    Weijia Fan
    Xinping Wang
    Xuelian Sun
    Jianmin Zhu
    Hongrui Zhou
    Huaying Wei
    Neurochemical Research, 2017, 42 : 2344 - 2353
  • [2] Differentiation of human umbilical cord-derived mesenchymal stem cells into hepatocytes in vitro
    Zheng, Guan
    Liu, Yang
    Jing, Qian
    Zhang, Lei
    BIO-MEDICAL MATERIALS AND ENGINEERING, 2015, 25 : S145 - S157
  • [3] Urothelial differentiation of human umbilical cord-derived mesenchymal stromal cells in vitro
    Wu, Shuai
    Cheng, Zhongliang
    Liu, Guohua
    Zhao, Xinfeng
    Zhong, Liang
    Zhu, Yingjian
    Zhu, Jiang
    ANALYTICAL CELLULAR PATHOLOGY, 2013, 36 (3-4) : 63 - 69
  • [4] In vitro hepatic differentiation of umbilical cord-derived mesenchymal stem cell
    Yoon, Hee-Hoon
    Jung, Bo-Young
    Seo, Young-Kwon
    Song, Kye-Yong
    Park, Jung-Keug
    PROCESS BIOCHEMISTRY, 2010, 45 (12) : 1857 - 1864
  • [5] The Effects of Indoxyl Sulfate on Human Umbilical Cord-Derived Mesenchymal Stem Cells In Vitro
    Wang, Wei
    Liu, Xueyong
    Wang, Wei
    Li, Jinghua
    Li, Yuanyuan
    Li, Liping
    Wang, Shaohua
    Zhang, Jianchun
    Zhang, Youkang
    Huang, Haichang
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2016, 38 (01) : 401 - 414
  • [6] Tetramethylpyrazine induces differentiation of human umbilical cord-derived mesenchymal stem cells into neuron-like cells in vitro
    Nan, Chengrui
    Guo, Li
    Zhao, Zongmao
    Ma, Shucheng
    Liu, Jixiang
    Yan, Dongdong
    Song, Guoqiang
    Liu, Hanjie
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2016, 48 (06) : 2287 - 2294
  • [7] Tenogenic Differentiation Of Umbilical Cord-derived and Adipose-derived Mesenchymal Stem Cells
    Baek, M.
    Kim, J.
    Ahn, M.
    Lee, S.
    Min, K.
    TISSUE ENGINEERING PART A, 2017, 23 : S71 - S72
  • [8] The Role of the Notch Signaling Pathway in the Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells
    Xing, Wanhong
    Yang, Jianxin
    Zheng, Ying
    Yao, Lin
    Peng, Xin
    Chen, Yongqiang
    Yang, Chao
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2024, 29 (02):
  • [9] Human umbilical cord-derived mesenchymal stem cells can secrete insulin in vitro and in vivo
    Boroujeni, Zahra Niki
    Aleyasin, Ahmad
    BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2014, 61 (02) : 82 - 92
  • [10] Optimization of in vitro cell labeling methods for human umbilical cord-derived mesenchymal stem cells
    Tao, R.
    Sun, T. -J.
    Han, Y. -Q.
    Xu, G.
    Liu, J.
    Han, Y. -F.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2014, 18 (08) : 1127 - 1134
12345