Presynaptic inhibition by muscimol through GABAB receptors

被引:39
|
作者
Yamauchi, T [1 ]
Hori, T [1 ]
Takahashi, T [1 ]
机构
[1] Univ Tokyo, Fac Med, Dept Neurophysiol, Tokyo 1130033, Japan
关键词
calyx of Held; GABA(B) receptors; muscimol; presynaptic inhibition;
D O I
10.1046/j.1460-9568.2000.00248.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The gamma-aminobutyric acid type A (GABA(A)) receptor agonist muscimol is widely used as a tool for reducing neuronal activities particularly in experiments in vivo. At the synapse formed by the calyx of Held in the rat brainstem slice, the GABA(A) receptor agonist muscimol (> 10 mu m) attenuated the amplitude of excitatory post synaptic currents (EPSCs) accompanied by an increase in the coefficient of Variation of EPSCs, suggesting its presynaptic inhibitory effect. This muscimol effect was not affected by bicuculline but occluded the presynaptic inhibitory effect of the GABA(B) receptor agonist baclofen and was abolished by the type B GABA (GABA(B)) receptor-specific antagonist (+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911; 20 mu M) We conclude that muscimol activates presynaptic GABA(B) receptors thereby attenuating synaptic transmission.
引用
收藏
页码:3433 / 3436
页数:4
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