Gene polymorphism affecting α1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk

被引：0
|
作者：
Licastro, F
Pedrini, S
Ferri, C
Casadei, V
Govoni, M
Pession, A
Sciacca, FL
Veglia, F
Annoni, G
Bonafe, M
Olivieri, F
Franceschi, C
Grimaldi, LME
机构：
[1] Univ Bologna, Sch Med, Dipartimento Patol Sperimentale, I-40126 Bologna, Italy
[2] Hosp San Raffaele, Neuroimmunol Unit, Dept Neurosci, I-20132 Milan, Italy
[3] Univ Milan, Dept Geriatr, Milan, Italy
[4] Inst Natl Ric & Ricovero Anziani, Ancona, Italy
来源：
ANNALS OF NEUROLOGY | 2000年 / 48卷 / 03期
关键词：
D O I：
10.1002/1531-8249(200009)48:3<388::AID-ANA16>3.3.CO;2-7
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Plasma levels of al-antichymotrypsin (ACT) and interleukin-1 beta (IL-1 beta) were increased in patients with probable Alzheimer's disease (AD). A common polymorphism within ACT and IL-IP genes affected plasma levels of ACT or IL-1 beta, and AD patients with the ACT T,T or IL-1 beta T,T genotype show-ed the highest levels of plasma ACT or IL-1 beta, respectively. The concomitant presence of the ACT T,T and IL-1 beta T,T genotypes increased the risk of AD (odds ratio: 5.606, confidence interval: 1.654-18.996) and decreased the age at onset of the disease.
引用
收藏
页码：388 / 391
页数：4
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