Membrane-Binding Peptide Inhibits Blockage of Mitochondrial VDAC by Alpha-Synuclein: In Search of A-Synuclein Toxicity Prevention

被引：0
|
作者：
Gurnev, Philip [1 ,2 ]
Hoogerheide, David [1 ,3 ]
Rostovtseva, Tatiana [1 ]
Bezrukov, Sergey [1 ]
机构：
[1] NICHHD, Bethesda, MD 20892 USA
[2] Univ Massachusetts, Phys, Amherst, MA 01003 USA
[3] NIST, Ctr Neutron Res, Gaithersburg, MD 20899 USA
来源：
BIOPHYSICAL JOURNAL | 2016年 / 110卷 / 03期
关键词：
D O I：
10.1016/j.bpj.2015.11.2521
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
2320-Pos
引用
收藏
页码：471A / 471A
页数：1
相关论文
共 45 条
  • [21] Effects of Membrane Binding and Post-Translational Modifications on Alpha-Synuclein Toxicity in Parkinson's Disease
    Rochet, J. C.
    Strathearn, K.
    Griggs, A.
    Hindupur, J.
    Schieler, J.
    Head, K.
    MOVEMENT DISORDERS, 2010, 25 : S622 - S623
  • [22] Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding
    Robotta, Marta
    Cattani, Julia
    Martins, Juliana Cristina
    Subramaniam, Vinod
    Drescher, Make
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017, 139 (12) : 4254 - 4257
  • [23] Modelling Ser129 Phosphorylation Inhibits Membrane Binding of Pore-Forming Alpha-Synuclein Oligomers
    Nuebling, Georg Sebastian
    Levin, Johannes
    Bader, Benedikt
    Lorenzl, Stefan
    Hillmer, Andreas
    Hoegen, Tobias
    Kamp, Frits
    Giese, Armin
    PLOS ONE, 2014, 9 (06):
  • [24] Outcomes of acetylation and nitration for alpha-synuclein's membrane binding and phase behavior
    Kim, Sadie C.
    Katz, Jean R.
    Ponte, Alana T.
    Londergan, Casey H.
    BIOPHYSICAL JOURNAL, 2024, 123 (03) : 218A - 218A
  • [25] Alpha-synuclein preference for lipid packing defects over charge for membrane binding
    Turke, Miah J.
    Kerr, Daniel H.
    Slaw, Benjamin R.
    Maltseva, Sofiya
    Raghavan, Krishna M.
    Lee, Ka Yee C.
    BIOPHYSICAL JOURNAL, 2024, 123 (03) : 93A - 93A
  • [26] Alpha-Synuclein Transmission and Mitochondrial Toxicity in Primary Human Foetal Enteric Neurons In Vitro
    Braidy, Nady
    Gai, Wei-Ping
    Xu, Ying Hua
    Sachdev, Perminder
    Guillemin, Gilles J.
    Jiang, Xing-Mai
    Ballard, J. William O.
    Horan, Martin P.
    Fang, Zhi Ming
    Chong, Beng H.
    Chan, Daniel Kam Yin
    NEUROTOXICITY RESEARCH, 2014, 25 (02) : 170 - 182
  • [27] Alpha-Synuclein Transmission and Mitochondrial Toxicity in Primary Human Foetal Enteric Neurons In Vitro
    Nady Braidy
    Wei-Ping Gai
    Ying Hua Xu
    Perminder Sachdev
    Gilles J. Guillemin
    Xing-Mai Jiang
    J. William O. Ballard
    Martin P. Horan
    Zhi Ming Fang
    Beng H. Chong
    Daniel Kam Yin Chan
    Neurotoxicity Research, 2014, 25 : 170 - 182
  • [28] The Role of Membrane Affinity and Binding Modes in Alpha-Synuclein Regulation of Vesicle Release and Trafficking
    Das, Tapojyoti
    Ramezani, Meraj
    Snead, David
    Follmer, Cristian
    Chung, Peter
    Lee, Ka Yee
    Holowka, David A. A.
    Baird, Barbara A. A.
    Eliezer, David
    BIOMOLECULES, 2022, 12 (12)
  • [29] Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils
    Ardah, Mustafa T.
    Paleologou, Katerina E.
    Lv, Guohua
    Menon, Sindhu A.
    Abul Khair, Salema B.
    Lu, Jia-Hong
    Safieh-Garabedian, Bared
    Al-Hayani, Abdulmonem A.
    Eliezer, David
    Li, Min
    El-Agnaf, Omar M. A.
    NEUROBIOLOGY OF DISEASE, 2015, 74 : 89 - 101
  • [30] Alpha-Synuclein Lipid-Dependent Membrane Binding and Translocation through the α-Hemolysin Channel
    Gurnev, Philip A.
    Yap, Thai Leong
    Pfefferkorn, Candace M.
    Rostovtseva, Tatiana K.
    Berezhkovskii, Alexander M.
    Lee, Jennifer C.
    Parsegian, V. Adrian
    Bezrukov, Sergey M.
    BIOPHYSICAL JOURNAL, 2014, 106 (03) : 556 - 565
12345