Synthesis and applications of cell-penetrating peptide-PNA conjugates

被引：0

作者：

Jiang, Y ^{[1
]}

Sassian, M ^{[1
]}

Langel, Ü ^{[1
]}

机构：

[1] Stockholm Univ, Dept Neurochem & Neurotoxicol, SE-10691 Stockholm, Sweden

来源：

CHIMICA OGGI-CHEMISTRY TODAY | 2004年 / 22卷 / 7-8期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Peptide nucleic acids (PNA) are highly potential to be applied in antisense and anti-gene strategie. However, limited cellular uptake hinders applications of PNA in this purpose. Cell-penetrating peptides (CPP), short peptides that have the ability to translocate into cell membranes with cargo molecules, are able to translocate conjugated PNA oligomers into cells. Various CPP-PNA conjugates have been synthesized and showed increased cellular uptake and biological effects in gene silencing.

引用

页码：36 / 39

页数：4

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