Studies of cubosomes as a sustained drug delivery system

被引：35
|
作者：
Zhao, XY [1 ]
Zhang, J [1 ]
Zheng, LQ [1 ]
Li, DH [1 ]
机构：
[1] Shandong Univ, Minist Educ, Key Lab Colloid & Interface Chem, Jinan 250100, Peoples R China
来源：
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2004年 / 25卷 / 06期
关键词：
cubic particles; monoolein; chloramphenicol; negative-staining TEM; small angle x-ray diffraction; cubosomes;
D O I：
10.1081/DIS-200035589
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The morphologies of cubosome particles, formed by dispersing monoolein/F127/ ethanol mixtures into water, was investigated by negative-staining transmission electron microscope (TEM), and the structures of the particles were characterized by small angle x-ray diffraction (XRD). It was revealed that aqueous dispersions of the monoolein/F127/ethanol mixture are particles with irregular cubic shape. It was also found that the particles still retain the cubic phase feature. With addition of different amounts and kinds of block copolymer to the monoolein/ethanol mixture, the release efficiencies of chloramphenicol from these cubosomes were also studied.
引用
收藏
页码：795 / 799
页数：5
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