Automation of biomolecular NMR screening

被引：8

作者：

Ross, A ^{[1
]}

Senn, H ^{[1
]}

机构：

[1] Hoffmann La Roche AG, Dept Biostruct Res, PRBT, CH-4070 Basel, Switzerland

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 01期

关键词：

NMR; ligand; protein; screening; automation; PCA;

D O I：

10.2174/1568026033392688

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

For NMR based screening we review equipment needed for automated preparation of samples and acquisition of a large number of data sets. Hardware connecting lab-bench and NMR spectrometer is described. We focus on software used for automated calculation of the similarity between spectra - a prerequisite for the identification of test compounds interacting with a target-molecule.

引用

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页码：55 / 67

页数：13

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