Comparison of liver fibrosis progression in HIV/HCV co-infected and HCV mono-infected patients by transient elastometry

被引：3
|
作者：
Mazzocato, Susanna [1 ]
Orsetti, Elena [1 ]
Gesuita, Rosaria [2 ]
Piraccini, Francesca [2 ]
Drenaggi, Davide [1 ]
Barchiesi, Francesco [1 ]
机构：
[1] Univ Politecn Marche, Clin Malattie Infett, Ancona, Italy
[2] Univ Politecn Marche, Ctr Epidemiol Biostat & Informat Med, Ancona, Italy
来源：
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 2014年 / 46卷 / 11期
关键词：
HIV/HCV co-infection; liver fibrosis; transient elastometry; CHRONIC HEPATITIS-C; ANTIRETROVIRAL THERAPY; COINFECTED PATIENTS; ELASTOGRAPHY FIBROSCAN; NONINVASIVE TESTS; RISK-FACTORS; VIRUS; HIV; BIOPSY; DISEASE;
D O I：
10.3109/00365548.2014.952245
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Monitoring of liver fibrosis (LF) is an essential tool for preventing liver-related complications in HIV/HCV co-infected patients. In this study, we compared LF progression by transient elastometry (TE) in 50 HIV/HCV co-infected and 115 HCV mono-infected patients followed in our institution between June 2006 and December 2011. Patients naive to interferon therapy and with at least two measurements of liver stiffness by TE were included. In all, 76% of HIV/HCV co-infected and 75% of HCV mono-infected patients remained in the same stage of LF over time. Conversely, 19% and 15% of HIV/HCV co-infected and HCV mono-infected subjects, respectively, had progression to advanced LF (>= F3). Our study found a similar proportion of HIV/HCV co-infected and HCV mono-infected patients that developed an advanced LF during the follow-up time considered. Alcohol abuse was the only factor significantly associated with the progression as evidenced by multiple quantile regression analysis.
引用
收藏
页码：797 / 802
页数：6
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