A rapid and high efficient microwave promoted multicomponent domino reaction for the synthesis of spirooxindole derivatives

被引：14
|
作者：
Ghahremanzadeh, Ramin [1 ]
Rashid, Zahra [2 ]
Zarnani, Amir-Hassan [3 ]
Naeimi, Hossein [2 ]
机构：
[1] ACECR, Avicenna Res Inst, Nanobiotechnol Res Ctr, Tehran, Iran
[2] Univ Kashan, Fac Chem, Dept Organ Chem, Kashan 87317, Iran
[3] ACECR, Avicenna Res Inst, Reprod Immunol Res Ctr, Tehran, Iran
来源：
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | 2014年 / 20卷 / 06期
关键词：
Multi-component reaction; Alum [KAl(SO4)(2)center dot 12H(2)O; Microwave; Anilinolactone; Spirooxindole; ONE-POT SYNTHESIS; FACILE SYNTHESIS; INDOLE; INHIBITOR; CATALYST; WATER;
D O I：
10.1016/j.jiec.2013.12.109
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple, efficient and rapid method has been developed for synthesis of 6,6-dimethyl-4-phenyl-6,7-dihydro-1H-spiro[furo[3,4-b]quinoline-9,3'-indoline]1,2',8(3H,4H,5H)-trione derivatives. These heterocycles were prepared through domino one-pot and multicomponent condensation reactions of isatins, dimedone, and anilinolactones in the presence of alum (15 mol%) as an inexpensive, nontoxic, convenient, and available Lewis acid catalyst under microwave irradiation. The corresponding products have been obtained in excellent isolated yields between 78% and 90%, with high purity, in short reaction times about 10-12 min and easy work up. (C) 2014 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：4076 / 4084
页数：9
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